Feasibility of Quantitative Biometric Assessment Following Cold Atmospheric Spark Plasma Rejuvenation: A Single‑Case Report on the Aging Periorbital and Nasolabial Regions Publisher



Hoghough A S ; Nilforoushzadeh M A ; Khani M ; Amirkhani M A ; Shokri B ; Savoji P B ; Ghasemi E ; Jafarzadeh A
Source: Plasma Medicine Published:2026

Abstract

Skin, beyond its visible appearance, possesses deeper structural properties that indicate the quality of the skin. Various factors such as collagen and elastic fibers can be used to assess the density and thickness of skin layers or to examine biometric features. This type of research requires medical devices such as an ultrasound imaging system or a variety of probes. The data obtained can then be used to investigate the causes of wrinkles. Numerous methods have been developed to make the skin smoother; however, researchers are still seeking a non‑invasive, practical approach that produces a lasting effect. Plasma, as an emerging field in medicine, has shown considerable potential in medical treatments, and its use for reducing skin wrinkles is being actively explored. Cold atmospheric plasma offers a solution for treating wrinkles with controlled thermal effects. In this context, spark plasma, which generates a strong electric current that interacts with skin layers, can be useful for improving skin biometric properties. This in vivo examination was performed using spark plasma to improve wrinkles in the crow’s feet and naso‑ labial areas. The results demonstrate that plasma can effectively maintain skin hydration, enhance elasticity parameters, and improve the thickness and density of skin layers. © 2026 by Begell House, Inc.