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The Impact of Heparin Therapy in Deceased Donors on Early Graft Survival for Kidney and Liver Recipients: A Clinical Trial Study Publisher Pubmed



Latifi M1 ; Pourhosein E2 ; Rahban H3, 4 ; Khajavi M5 ; Dehghani S2, 6
Authors
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Authors Affiliations
  1. 1. Medical Ethics and Law Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, 1985717443, Iran
  2. 2. Organ Procurement Unit, Sina Hospital, Tehran University of Medical Sciences, Tehran, 46911, Iran
  3. 3. Cardiovascular Research Foundation of Southern California, Beverly Hills, 90210, CA, United States
  4. 4. Southern California Medical Education Consortium, Temecula Valley Hospital, Universal Health System, Temecula, 92592, CA, United States
  5. 5. Anesthesia, Critical Care and Pain Management Research Center, Tehran University of Medical Sciences, Tehran, 1136746911, Iran
  6. 6. Iranian Tissue Bank & Research Center, Tehran University of Medical Sciences, Tehran, 1419733141, Iran

Source: Frontiers in Bioscience - Scholar Published:2023


Abstract

Background: Significant hemodynamic, hormonal, and metabolic impairment of a brain-dead organ donor is often associated with the deterioration of graft viability. This study aimed to compare the effect of heparin therapy as a therapeutic dose after brain death confirmation on early graft survival in kidney and liver recipients. Method and Materials: The deceased donors were sorted into two groups based on their D-dimer level. After confirming brain death, one group was given a heparin injection (case group), while the other group did not receive any heparin (control group). A total of 71 brain death donors and matched kidney and liver transplants were included in the case group. A total of 43 brain death donors and matched kidney and liver transplants were included in the control group. A total of 5000 units of heparin were administered every 6 hours to the deceased donor case group. Results: The mean age of the case and control groups were 36.27 ± 16.13 and 36.15 ± 18.45, respectively. An independent t test showed that there were no differences between the number of procured organs in both groups (p = 0.29). There was no significant difference between the graft survival rate and the doses of heparin injection to the liver recipients (p = 0.06). However, a significant difference was revealed between the graft survival rate and the dose of heparin injection (p = 0.004) in kidney recipients. Conclusions: The data suggest that administering low therapeutic doses of heparin to donors before organ donation may potentially prevent thrombosis and provide a protective benefit. We showed that heparin therapy had no significant effect on the number of donated organs and graft survival. Copyright: © 2023 The Author(s).
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3. Innate Inflammatory Gene Expression Profiling in Potential Brain-Dead Donors: Detailed Investigation of the Effect of Common Corticosteroid Therapy, Innate Immunity (2017)
4. Down-Regulation of Inflammatory Signaling Pathways Despite Up-Regulation of Toll-Like Receptors; the Effects of Corticosteroid Therapy in Brain-Dead Kidney Donors, a Double-Blind, Randomized, Controlled Trial, Molecular Immunology (2018)
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