The Effect of Dexamethasone on Labor Induction: A Systematic Review Publisher Pubmed



Mohaghegh Z¹ ; Faal Siahkal S² ; Bahmaei H³ ; Sharifipour F⁴ ; Leyli EK⁵ ; Zahedian M⁶
Source: BMC Pregnancy and Childbirth Published:2021

Abstract

Background: To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor. Methods: The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were searched for studies published up to June 27, 2021. Two types of articles were included: a) full-text articles published in English or any other languages, and b) Randomized Controlled Trials (RCTs). Participants were primi- or multigravida women with term or post-term pregnancy. The intervention group received parenteral or extra-amniotic dexamethasone whereas the control group received normal saline or no treatment before initiation of labor induction. All data were analyzed using Review Manager 5.3. Results: Seventeen studies involving 1879 patients were included in the meta-analysis. Administration of dexamethasone reduced the interval between the initiation of labor induction and the beginning of active phase by about 70 min [MD: - 1.17 (− 1.37, − 1.00); P < 0.00001]. Duration of the first stage of labor in the dexamethasone group was about 88 min shorter than that in the control. There were no maternal and fetal adverse effects. Conclusions: Dexamethasone could significantly reduce the length of induction-active phase interval, and length of the first stage of labor, with no difference in maternal or fetal adverse effects. © 2021, The Author(s).