A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy

A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy Publisher Pubmed

Gozubatikcelik RG¹ ; Sen S² ; Tay B³ ; Alroughani R⁴ ; Zakaria M⁵ ; Moghadasi AN^{6, 7} ; Terzi M² ; Koseoglu M¹ ; Efendi H⁸ ; Soysal A¹ ; Ozturk M¹ ; Akinci Y⁹ ; Kaya ZE⁹ ; Saip S⁸ Show All Authors

Gozubatikcelik RG¹
Sen S²
Tay B³
Alroughani R⁴
Zakaria M⁵
Moghadasi AN^{6, 7}
Terzi M²
Koseoglu M¹
Efendi H⁸
Soysal A¹
Ozturk M¹
Akinci Y⁹
Kaya ZE⁹
Saip S⁸
Siva A⁹
Sahraian M^{6, 7}
Gonen M¹⁰
Altintas A¹¹

Show Affiliations

1. Department of Neurology, University of Health Sciences Bakirkoy Prof. Dr. Mazhar Osman Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkey
2. Neurology Department, Ondokuz Mayis University School of Medicine, Samsun, Turkey
3. School of Medicine, Koc University, Istanbul, Turkey
4. Department of Neurology, Amiri Hospital, Sharq, Kuwait
5. Neurology Department, Ain-Shams University School of Medicine, Cairo, Egypt
6. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
7. Neurology Department, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
8. Department of Neurology, Kocaeli University School of Medicine, Kocaeli, Turkey
9. Istanbul University-Cerrahpasa, Cerrahpasa School of Medicine, Department of Neurology, Istanbul, Turkey
10. Department of Industrial Engineering, Koc University, College of Engineering, Istanbul, Turkey
11. Department of Neurology, School of Medicine, Koc University, Istanbul, Turkey

Source: Multiple Sclerosis and Related Disorders Published:2024

Abstract

Background: To investigate the pregnancy-related issues in females with multiple sclerosis (MS) from Turkiye, Egypt, Kuwait, and Iran. Methods: 1692 pregnancies of 701 females with MS were evaluated in this retrospective multicenter, international project. Demographics, clinical features, pregnancy outcomes, relapses, effects of exposure to disease-modifying drugs on pregnancy and fetus, and worries about pregnancy decisions were investigated. Results: 85.9 % of females were diagnosed with relapsing-remitting multiple sclerosis. The mean age was 39.0 ± 9.0 years (min 20, max 68). The mean EDSS score was 2.26 ± 1.8. The number of conceptions was inversely correlated with the level of education with significance (p < 0.05). Among the concerns related to pregnancy, 31.7 % pertain to disability progression, 14.4 % are associated with relapses, and 7.3 % involve the cessation of treatment. Additionally, 82.3 % of females with MS experienced no relapses during both pregnancy and the postpartum period. Most of the relapses (22.9 %) occurred in the postpartum period. Higher EDSS scores were detected in patients who have higher numbers of pre-MS period pregnancies (p = 0.042; r:0.2591). A similar correlation was found between the total number of pregnancies and higher EDSS levels (p = 0.003, r:0.2614). Considering the relationship between EDSS score and the number of pregnancies after MS diagnosis, no significance was found (p = 0.595). The age at first pregnancy did not affect the onset age of MS. Significant positive correlation was found between the age of onset and the total number of pregnancies and pre-MS pregnancies. As the number of pregnancies increased, the disease onset was at a later age (correlation = 0.4258). Conclusion: Presence of pre-MS pregnancies increased the age of onset of MS and caused more disability. The reduction in the number of pregnancies following the diagnosis of MS was related with a consistent hesitancy among patients in this regard. © 2024 Elsevier B.V.

2. Consensus Recommendations for the Diagnosis and Treatment of Multiple Sclerosis: 2019 Revisions to the Menactrims Guidelines, Multiple Sclerosis and Related Disorders (2020)

3. Consensus Recommendations for Diagnosis and Treatment of Multiple Sclerosis: 2023 Revision of the Menactrims Guidelines, Multiple Sclerosis and Related Disorders (2024)

4. Pregnancy and Motherhood Concerns Surrounding Women With Multiple Sclerosis: A Qualitative Content Analysis, International Journal of Community Based Nursing and Midwifery (2020)

5. Pregnancy Outcome in Patients With Multiple Sclerosis Treated With Rituximab: A Case-Series Study, Multiple Sclerosis and Related Disorders (2021)

6. Multiple Sclerosis: Clinical Features, Pathophysiology, Diagnosis, and Management, Neuroinflammation (2018)

7. Impact of Menopause on Relapse Rate and Disability Level in Patients With Multiple Sclerosis (Ms): A Systematic Review and Meta-Analysis, BMC Neurology (2023)

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Mohammad Ali Sahraian (4)

Amirreza Azimi (1)

Style	Citing Format
MLA	Gozubatikcelik RG, et al.. "A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy." Multiple Sclerosis and Related Disorders, vol. 91, no. , 2024, pp. -.
APA	Gozubatikcelik RG, Sen S, Tay B, Alroughani R, Zakaria M, Moghadasi AN, Terzi M, Koseoglu M, Efendi H, Soysal A, Ozturk M, Akinci Y, Kaya ZE, Saip S, Siva A, Sahraian M, Gonen M, Altintas A (2024). A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy. Multiple Sclerosis and Related Disorders, 91(), -.
Chicago	Gozubatikcelik RG, Sen S, Tay B, Alroughani R, Zakaria M, Moghadasi AN, Terzi M, et al.. "A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy." Multiple Sclerosis and Related Disorders 91, no. (2024): -.
Harvard	Gozubatikcelik RG et al. (2024) 'A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy', Multiple Sclerosis and Related Disorders, 91(), pp. -.
Vancouver	Gozubatikcelik RG, Sen S, Tay B, Alroughani R, Zakaria M, Moghadasi AN, et al.. A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy. Multiple Sclerosis and Related Disorders. 2024;91():-.
BibTex	@article{ author = {Gozubatikcelik RG and Sen S and Tay B and Alroughani R and Zakaria M and Moghadasi AN and Terzi M and Koseoglu M and Efendi H and Soysal A and Ozturk M and Akinci Y and Kaya ZE and Saip S and Siva A and Sahraian M and Gonen M and Altintas A}, title = {A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy}, journal = {Multiple Sclerosis and Related Disorders}, volume = {91}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Gozubatikcelik RG AU - Sen S AU - Tay B AU - Alroughani R AU - Zakaria M AU - Moghadasi AN AU - Terzi M AU - Koseoglu M AU - Efendi H AU - Soysal A AU - Ozturk M AU - Akinci Y AU - Kaya ZE AU - Saip S AU - Siva A AU - Sahraian M AU - Gonen M AU - Altintas A TI - A Multicenter Multinational Study to Evaluate Different Aspects of the Relationship Between Ms and Pregnancy JO - Multiple Sclerosis and Related Disorders VL - 91 IS - SP - EP - PY - 2024 ER -

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