Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity

Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity Publisher

Caracciolo G¹ ; Safavisohi R² ; Malekzadeh R³ ; Poustchi H³ ; Vasighi M⁴ ; Zenezini Chiozzi R⁵ ; Capriotti AL⁶ ; Lagana A⁶ ; Hajipour M² ; Di Domenico M^{7, 8} ; Di Carlo A⁹ ; Caputo D¹⁰ ; Aghaverdi H¹¹ ; Papi M¹⁰ Show All Authors

Caracciolo G¹
Safavisohi R²
Malekzadeh R³
Poustchi H³
Vasighi M⁴
Zenezini Chiozzi R⁵
Capriotti AL⁶
Lagana A⁶
Hajipour M²
Di Domenico M^{7, 8}
Di Carlo A⁹
Caputo D¹⁰
Aghaverdi H¹¹
Papi M¹⁰
Palmieri V¹⁰
Santoni A¹
Palchetti S¹
Digiacomo L¹
Pozzi D¹
Suslick KS¹²
Mahmoudi M^{2, 11}

Show Affiliations

1. Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, Rome, 00161, Italy
2. Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Computer Science and Information Technology, Institute for Advanced Studies in Basic Sciences, Zanjan, Iran
5. Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, Rome, 00185, Italy
6. Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Via S.M. Costantinopoli, 16, Naples, 80138, Italy
7. Department of Biology, Temple University's College of Science and Technology, Philadelphia, United States
8. Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Viale del Policlinico 155, Rome, 00161, Italy
9. University Campus Bio-Medico di Roma, General Surgery, Via Alvaro del Portillo 200, Rome, 00128, Italy
10. Institute of Physics, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Universita Cattolica Del Sacro Cuore, Rome, Italy
11. Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, 02115, MA, United States
12. Department of Chemistry, University of Illinois, Urbana-Champaign 600 South Mathews Avenue, Urbana, 61801, IL, United States

Source: Nanoscale Horizons Published:2019

Abstract

The earlier any catastrophic disease (e.g., cancer) is diagnosed, the more likely it can be treated, providing improved patient prognosis, extended survival and better quality of life. In early 2014, we revealed that various types of disease can substantially affect the composition/profile of protein corona (i.e., a layer of biomolecules that forms at the surface of nanoparticles upon their interactions with biological fluids). Here, by combining the concepts of disease-specific protein corona and sensor array technology we developed a platform with disease detection capacity using blood plasma. Our sensor array consists of three cross-reactive liposomes, with distinct lipid composition and surface charge. Rather than detecting a specific biomarker, the sensor array provides pattern recognition of the corona protein composition adsorbed on the liposomes. As a feasibility study, sensor array validation was performed using plasma samples obtained from patients diagnosed with five different cancer types (i.e. lung cancer, glioblastoma, meningioma, myeloma, and pancreatic cancer) and a control group of healthy donors. Although no single corona composition is specific for any one cancer type, overlapping but distinct patterns of the corona composition constitutes a unique fingerprint for each type of cancer (with a high classification accuracy, i.e. 99.4%). To finally probe the capacity of this sensor array for early detection of cancers, we used cohort plasma obtained from healthy people who were subsequently diagnosed several years after plasma collection with lung, brain, and pancreatic cancers. Our results suggest that the disease-specific protein corona sensor array will not only be instrumental in the screening, detection, and identification of diseases, but may also help identify novel protein pattern markers whose role in disease development and/or disease biology has not been appreciated so far. © 2019 The Royal Society of Chemistry.

Style	Citing Format
MLA	Caracciolo G, et al.. "Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity." Nanoscale Horizons, vol. 4, no. 5, 2019, pp. 1063-1076.
APA	Caracciolo G, Safavisohi R, Malekzadeh R, Poustchi H, Vasighi M, Zenezini Chiozzi R, Capriotti AL, Lagana A, Hajipour M, Di Domenico M, Di Carlo A, Caputo D, Aghaverdi H, Papi M, Palmieri V, Santoni A, Palchetti S, Digiacomo L, Pozzi D, ... Mahmoudi M (2019). Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity. Nanoscale Horizons, 4(5), 1063-1076.
Chicago	Caracciolo G, Safavisohi R, Malekzadeh R, Poustchi H, Vasighi M, Zenezini Chiozzi R, Capriotti AL, et al.. "Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity." Nanoscale Horizons 4, no. 5 (2019): 1063-1076.
Harvard	Caracciolo G et al. (2019) 'Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity', Nanoscale Horizons, 4(5), pp. 1063-1076.
Vancouver	Caracciolo G, Safavisohi R, Malekzadeh R, Poustchi H, Vasighi M, Zenezini Chiozzi R, et al.. Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity. Nanoscale Horizons. 2019;4(5):1063-1076.
BibTex	@article{ author = {Caracciolo G and Safavisohi R and Malekzadeh R and Poustchi H and Vasighi M and Zenezini Chiozzi R and Capriotti AL and Lagana A and Hajipour M and Di Domenico M and Di Carlo A and Caputo D and Aghaverdi H and Papi M and Palmieri V and Santoni A and Palchetti S and Digiacomo L and Pozzi D and Suslick KS and Mahmoudi M}, title = {Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity}, journal = {Nanoscale Horizons}, volume = {4}, number = {5}, pages = {1063-1076}, year = {2019} }
RIS	TY - JOUR AU - Caracciolo G AU - Safavisohi R AU - Malekzadeh R AU - Poustchi H AU - Vasighi M AU - Zenezini Chiozzi R AU - Capriotti AL AU - Lagana A AU - Hajipour M AU - Di Domenico M AU - Di Carlo A AU - Caputo D AU - Aghaverdi H AU - Papi M AU - Palmieri V AU - Santoni A AU - Palchetti S AU - Digiacomo L AU - Pozzi D AU - Suslick KS AU - Mahmoudi M TI - Disease-Specific Protein Corona Sensor Arrays May Have Disease Detection Capacity JO - Nanoscale Horizons VL - 4 IS - 5 SP - 1063 EP - 1076 PY - 2019 ER -

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Abstract