Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems

Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems Publisher

Moghimi S¹ ; Goligarmroodi F¹ ; Pilali H¹ ; Mahdavi M² ; Firoozpour L² ; Nadri H³ ; Moradi A³ ; Asadipour A⁴ ; Shafiee A¹ ; Foroumadi A^{1, 4}

Show Affiliations

1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

Source: Journal of Chemical Sciences Published:2016

Abstract

An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase (AChE) inhibitory activities of the target compounds were screened by Ellman’s method. [Figure not available: see fulltext.] © 2016, Indian Academy of Sciences.

Style	Citing Format
MLA	Moghimi S, et al.. "Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems." Journal of Chemical Sciences, vol. 128, no. 9, 2016, pp. 1445-1449.
APA	Moghimi S, Goligarmroodi F, Pilali H, Mahdavi M, Firoozpour L, Nadri H, Moradi A, Asadipour A, Shafiee A, Foroumadi A (2016). Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems. Journal of Chemical Sciences, 128(9), 1445-1449.
Chicago	Moghimi S, Goligarmroodi F, Pilali H, Mahdavi M, Firoozpour L, Nadri H, Moradi A, Asadipour A, Shafiee A, Foroumadi A. "Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems." Journal of Chemical Sciences 128, no. 9 (2016): 1445-1449.
Harvard	Moghimi S et al. (2016) 'Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems', Journal of Chemical Sciences, 128(9), pp. 1445-1449.
Vancouver	Moghimi S, Goligarmroodi F, Pilali H, Mahdavi M, Firoozpour L, Nadri H, et al.. Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems. Journal of Chemical Sciences. 2016;128(9):1445-1449.
BibTex	@article{ author = {Moghimi S and Goligarmroodi F and Pilali H and Mahdavi M and Firoozpour L and Nadri H and Moradi A and Asadipour A and Shafiee A and Foroumadi A}, title = {Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems}, journal = {Journal of Chemical Sciences}, volume = {128}, number = {9}, pages = {1445-1449}, year = {2016} }
RIS	TY - JOUR AU - Moghimi S AU - Goligarmroodi F AU - Pilali H AU - Mahdavi M AU - Firoozpour L AU - Nadri H AU - Moradi A AU - Asadipour A AU - Shafiee A AU - Foroumadi A TI - Synthesis and Anti-Acetylcholinesterase Activity of Benzotriazinone-Triazole Systems JO - Journal of Chemical Sciences VL - 128 IS - 9 SP - 1445 EP - 1449 PY - 2016 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract