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Improving Quality of Life for Transfemoral Amputees: Results From a Two-Year Study of the Opra Implant System and Rehabilitation Protocol Publisher Pubmed



Mortazavi SMJ1 ; Abbaspour A1 ; Seyedtabaei SMM1 ; Saberi S1, 2 ; Khabiri SS1, 3
Authors
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Authors Affiliations
  1. 1. Department of Orthopedic Surgery, Joint Reconstruction Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran, 1419733141, Iran
  2. 2. Orthopedic Oncologic Department, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: European Journal of Orthopaedic Surgery and Traumatology Published:2025


Abstract

Purpose: Transfemoral amputees face significant functional limitations with traditional socket prostheses. This study evaluates the efficacy and safety of the OPRA (Osseointegrated Prostheses for the Rehabilitation of Amputees) implant system in improving the quality of life for these patients. Methods: A retrospective study was conducted on 22 transfemoral amputees (20 male, 2 female; mean age 44.6 years) who underwent OPRA implant surgery between 2019 and 2021. Patients were assessed preoperatively and followed for two years post-surgery. Outcomes were measured using the Questionnaire for Persons with a Transfemoral Amputation (Q-TFA), pain scores, and complication rates. Results: At two-year follow-up, significant improvements were observed in Q-TFA scores for prosthetic use (30.41 ± 10.90 to 87.68 ± 11.42, p < 0.001), mobility (44.36 ± 15.57 to 71.45 ± 13.72, p < 0.001), problem score (52.40 ± 10.22 to 25.81 ± 9.66, p < 0.001), and global score (43.45 ± 10.87 to 74.95 ± 21.82, p < 0.001). Mean daily prosthesis usage increased from 3.77 ± 2.59 to 13.43 ± 3.76 h (p < 0.001). Complications included minor discharge (67.5%), significant discharge requiring surgical intervention (13.6%), prosthesis removal (9%), and periprosthetic fracture (4.5%). Conclusion: The OPRA implant system significantly improved functional outcomes and quality of life for transfemoral amputees over two years. While complication rates were notable, most were manageable with conservative treatment. These findings suggest that osseointegrated prostheses offer a promising alternative to socket prostheses for suitable candidates, though further research with larger cohorts is warranted to confirm long-term efficacy and safety. © The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature 2025.