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One Side Ovarian Rejuvenation: A Quasi-Experimental Study of the Effect of the Autologous Platelet Rich Plasma in Poor Ovarian Responders in Ivf Publisher Pubmed



Keikha F1 ; Shahsavari S1, 2 ; Salari Y3 ; Roozbeh N4 ; Haghollahi F1 ; Tarazjani MD1 ; Razavi M5 ; Shariat M6 ; Bagheri M1
Authors
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Authors Affiliations
  1. 1. Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  3. 3. Brighton and Sussex Medical School, Brighton, United Kingdom
  4. 4. Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  5. 5. Department of Obstetrics & Gynecology, Ardebil University of Medical Sciences
  6. 6. Maternal, Fetal & Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Ethiopian journal of health sciences Published:2022


Abstract

Background: The poor ovarian response is the most important limiting factor in the success of in vitro fertilization (IVF). The aim of this study was to evaluate the outcome of intraovarian injection of autologous platelet-rich plasma (aPRP) on the oocyte number and IVF outcomes in poor ovarian responders (POR). Methods: This quasi-experimental study was performed from August 2021 to December 2021, in Vali-e-Asr Infertility Clinic affiliated with Tehran University of Medical Sciences, Tehran, Iran. There were 12 POR patients selected based on the criteria of Bologna group 4 who underwent two IVF cycles with similar antagonist regimens in a 70-day-interval. Immediately after the Oocytes Pick-Up (OPU), there was a 4cc of autologous PRP multifocal intramedullary injection done into their right ovaries in the first IVF cycle (case group). On the other hand, their left ovaries were considered as the control group. The patients underwent the second IVF cycle after 70 days. Results: Those who had undergone aPRP experienced a significant increase of the mean of antral follicular count (AFC) (from 1.91±0.79 to 2.50±0.90, p=0.043). There was a significant increase in the number of embryos from the right ovary (intervention group) compared to the left ovary (control group) after PRP, but there was no significant difference in the number of embryos in the right ovary before and after the intervention (from 0.25 ±0.45 to 1.08±0.79, p=0.705). There was no significant change in the number of oocytes, AMH, and FSH in the case and control groups before and after the intervention (p>0.05). Conclusion: According to the results of this study, it seems that in females with POR, intraovarian aPRP had no effect on the outcomes (embryos number, number of oocytes, FSH and AMH level), except for an increase in AFC. © 2022 Keikha F., et al.