Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies

Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies Publisher Pubmed

Mohammadi AA¹ ; Taheri S¹ ; Shisheboran S¹ ; Ahdenov R¹ ; Mohammadikhanaposhtani M² ; Darjani PS³ ; Masihi PH⁴ ; Shakiba A⁴ ; Larijani B⁵ ; Mahdavi M⁵ ; Ahangar N^{6, 7}

Show Affiliations

1. Chemistry and Chemical Engineering Research Center of Iran (CCERCI), Tehran, Iran
2. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3. Student Researches Committee, Guilan University of Medical Sciences, Rasht, Iran
4. Student Researches Committee, Mazandaran University of Medical Sciences, Ramsar Campus, Ramsar, Iran
5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
6. Cellular &Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
7. Department of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Source: Journal of Biochemical and Molecular Toxicology Published:2023

Abstract

A new series of spiro[indene-1,2′-quinazolin]-4′(3′H)-one derivatives 4a–m were synthesized via a one-pot method and evaluated for anticonvulsant activities using pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures. Obtained results demonstrated that these compounds have not anticonvulsant activity in PTZ test while are active in the MES test. Among the synthesized compounds, the best anticonvulsant activity was obtained with compound 4h. This compound also was not neurotoxic. Given that the title new compounds have the pharmacophore requirement for benzodiazepine (BZD) receptor agonist, the most potent compound was assayed in vivo and in silico as BZD receptor agonist. After treatment with flumazenil as a standard BZD receptor antagonist, anticonvulsant activity of compound 4h decreased. Therefore, the involvement of BZD receptors in anticonvulsant activity of this compound confirmed. Furthermore, docking study of compound 4h in the BZD-binding site of GABAA receptor confirmed that this compound interacted with the important residues. © 2022 Wiley Periodicals LLC.

Style	Citing Format
MLA	Mohammadi AA, et al.. "Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies." Journal of Biochemical and Molecular Toxicology, vol. 37, no. 1, 2023, pp. -.
APA	Mohammadi AA, Taheri S, Shisheboran S, Ahdenov R, Mohammadikhanaposhtani M, Darjani PS, Masihi PH, Shakiba A, Larijani B, Mahdavi M, Ahangar N (2023). Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies. Journal of Biochemical and Molecular Toxicology, 37(1), -.
Chicago	Mohammadi AA, Taheri S, Shisheboran S, Ahdenov R, Mohammadikhanaposhtani M, Darjani PS, Masihi PH, et al.. "Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies." Journal of Biochemical and Molecular Toxicology 37, no. 1 (2023): -.
Harvard	Mohammadi AA et al. (2023) 'Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies', Journal of Biochemical and Molecular Toxicology, 37(1), pp. -.
Vancouver	Mohammadi AA, Taheri S, Shisheboran S, Ahdenov R, Mohammadikhanaposhtani M, Darjani PS, et al.. Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies. Journal of Biochemical and Molecular Toxicology. 2023;37(1):-.
BibTex	@article{ author = {Mohammadi AA and Taheri S and Shisheboran S and Ahdenov R and Mohammadikhanaposhtani M and Darjani PS and Masihi PH and Shakiba A and Larijani B and Mahdavi M and Ahangar N}, title = {Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies}, journal = {Journal of Biochemical and Molecular Toxicology}, volume = {37}, number = {1}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Mohammadi AA AU - Taheri S AU - Shisheboran S AU - Ahdenov R AU - Mohammadikhanaposhtani M AU - Darjani PS AU - Masihi PH AU - Shakiba A AU - Larijani B AU - Mahdavi M AU - Ahangar N TI - Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies JO - Journal of Biochemical and Molecular Toxicology VL - 37 IS - 1 SP - EP - PY - 2023 ER -

Style

Citing Format

MLA

Mohammadi AA, et al.. "Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies." Journal of Biochemical and Molecular Toxicology, vol. 37, no. 1, 2023, pp. -.

APA

Mohammadi AA, Taheri S, Shisheboran S, Ahdenov R, Mohammadikhanaposhtani M, Darjani PS, Masihi PH, Shakiba A, Larijani B, Mahdavi M, Ahangar N (2023). Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies. Journal of Biochemical and Molecular Toxicology, 37(1), -.

Chicago

Mohammadi AA, Taheri S, Shisheboran S, Ahdenov R, Mohammadikhanaposhtani M, Darjani PS, Masihi PH, et al.. "Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies." Journal of Biochemical and Molecular Toxicology 37, no. 1 (2023): -.

Harvard

Mohammadi AA et al. (2023) 'Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies', Journal of Biochemical and Molecular Toxicology, 37(1), pp. -.

Vancouver

Mohammadi AA, Taheri S, Shisheboran S, Ahdenov R, Mohammadikhanaposhtani M, Darjani PS, et al.. Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies. Journal of Biochemical and Molecular Toxicology. 2023;37(1):-.

BibTex

@article{ author = {Mohammadi AA and Taheri S and Shisheboran S and Ahdenov R and Mohammadikhanaposhtani M and Darjani PS and Masihi PH and Shakiba A and Larijani B and Mahdavi M and Ahangar N}, title = {Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies}, journal = {Journal of Biochemical and Molecular Toxicology}, volume = {37}, number = {1}, pages = {-}, year = {2023} }

RIS

TY - JOUR
AU - Mohammadi AA
AU - Taheri S
AU - Shisheboran S
AU - Ahdenov R
AU - Mohammadikhanaposhtani M
AU - Darjani PS
AU - Masihi PH
AU - Shakiba A
AU - Larijani B
AU - Mahdavi M
AU - Ahangar N
TI - Novel Spiro[Indene-1,2′-Quinazolin]-4′(3′H)-One Derivatives As Potent Anticonvulsant Agents: One-Pot Synthesis, in Vivo Biological Evaluation, and Molecular Docking Studies
JO - Journal of Biochemical and Molecular Toxicology
VL - 37
IS - 1
SP -
EP -
PY - 2023
ER -

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