Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case

Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study Publisher

Harsini AR¹ ; Mohajeritehrani MR² ; Sajjadijazi SM² ; Naeini F¹ ; Valisoltani N¹ ; Sadeghi E³ ; Mohammadi H¹ ; Hosseini S¹

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1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Research Consultation Center (RCC), Shiraz University of Medical Sciences, Shiraz, Iran

Source: Clinical Nutrition ESPEN Published:2024

Abstract

Background: It is unclear whether variation in thyroid stimulating hormone (TSH) levels within the reference range affect energy expenditure and clinical symptoms and even within the normal range of TSH levels, resting energy expenditure may alter. The aim of the present study was to determine whether treated hypothyroid subjects and healthy subjects with a low-normal TSH range (0.3–2.3 mIU/L) have better clinical outcomes and increased energy expenditure than those with a high-normal TSH range (2.3–4.3 mIU/L). Methods: This was a case–control study of 160 overweight/obese women with TSH levels across the reference range of 0.3–4.3 mU/l. Subjects were paired in four groups: healthy subjects with low-normal target TSH (n = 40), healthy subjects with high-normal target TSH (n = 40), subjects with treated hypothyroidism with low-normal target TSH (n = 40), and subjects with treated hypothyroidism with high-normal target TSH (n = 40). Resting energy expenditure (RMR), dietary intake, body composition, physical activity, and biochemical markers were assessed. Results: Subjects with low-normal (≤2.3 mU/L) and high-normal (>2.3 mU/L) TSH levels did not differ in terms of RMR, serum T3 levels, and clinical symptoms except fatigue (P = 0.013). However, serum fT4 levels were found to be significantly different between the study groups (P = 0.002). Serum fT4 concentration was the highest in subjects with treated hypothyroidism with low-normal target TSH. Conclusion: Variation in serum TSH levels within the reference range did not significantly affect REE and clinical symptoms except fatigue in healthy and women with hypothyroidism. © 2024 European Society for Clinical Nutrition and Metabolism

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Style	Citing Format
MLA	Harsini AR, et al.. "Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study." Clinical Nutrition ESPEN, vol. 61, no. , 2024, pp. 71-78.
APA	Harsini AR, Mohajeritehrani MR, Sajjadijazi SM, Naeini F, Valisoltani N, Sadeghi E, Mohammadi H, Hosseini S (2024). Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study. Clinical Nutrition ESPEN, 61(), 71-78.
Chicago	Harsini AR, Mohajeritehrani MR, Sajjadijazi SM, Naeini F, Valisoltani N, Sadeghi E, Mohammadi H, Hosseini S. "Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study." Clinical Nutrition ESPEN 61, no. (2024): 71-78.
Harvard	Harsini AR et al. (2024) 'Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study', Clinical Nutrition ESPEN, 61(), pp. 71-78.
Vancouver	Harsini AR, Mohajeritehrani MR, Sajjadijazi SM, Naeini F, Valisoltani N, Sadeghi E, et al.. Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study. Clinical Nutrition ESPEN. 2024;61():71-78.
BibTex	@article{ author = {Harsini AR and Mohajeritehrani MR and Sajjadijazi SM and Naeini F and Valisoltani N and Sadeghi E and Mohammadi H and Hosseini S}, title = {Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study}, journal = {Clinical Nutrition ESPEN}, volume = {61}, number = {}, pages = {71-78}, year = {2024} }
RIS	TY - JOUR AU - Harsini AR AU - Mohajeritehrani MR AU - Sajjadijazi SM AU - Naeini F AU - Valisoltani N AU - Sadeghi E AU - Mohammadi H AU - Hosseini S TI - Are Resting Metabolic Rate and Clinical Symptoms Affected by Variation of Serum Thyroid Stimulating Hormone Levels Within the Normal Range in Healthy and Women With Hypothyroidism? a Case–Control Study JO - Clinical Nutrition ESPEN VL - 61 IS - SP - 71 EP - 78 PY - 2024 ER -

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