Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature

Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature Publisher

Safavi M ; Naderi Z ; Sharari AS ; Parvaneh N ; Naderi F

Source: Published:2025

Abstract

Introduction: GATA 2 deficiency syndrome is an autosomal dominant genetic disease principally known as a bone marrow and immune system disorder. GATA-2 is a hematopoietic transcription factor; patients with this syndrome are prone to acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). Case Presentation: Here we describe a teenage girl with GATA2 deficiency syndrome and pyoderma gangrenosum (PG) in the background of childhood myelodysplastic syndrome (cMDS) as a first presentation. Conclusions: In patients with sustained, unexplained skin lesions, especially with cytopenia, PG should be kept in mind. A bone marrow biopsy might help rule out hematologic disorders, including MDS. The MDS in children usually occurs in the context of hereditary disorders of bone marrow. Therefore, it seems wise to perform genetic testing in cMDS. © 2025 Elsevier B.V., All rights reserved.

Style	Citing Format
MLA	Safavi M, et al.. "Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature." , vol. 35, no. 5, 2025, pp. -.
APA	Safavi M, Naderi Z, Sharari AS, Parvaneh N, Naderi F (2025). Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature. , 35(5), -.
Chicago	Safavi M, Naderi Z, Sharari AS, Parvaneh N, Naderi F. "Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature." 35, no. 5 (2025): -.
Harvard	Safavi M et al. (2025) 'Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature', , 35(5), pp. -.
Vancouver	Safavi M, Naderi Z, Sharari AS, Parvaneh N, Naderi F. Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature. . 2025;35(5):-.
BibTex	@article{ author = {Safavi M and Naderi Z and Sharari AS and Parvaneh N and Naderi F}, title = {Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature}, journal = {}, volume = {35}, number = {5}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Safavi M AU - Naderi Z AU - Sharari AS AU - Parvaneh N AU - Naderi F TI - Pyoderma Gangrenosum As the First Sign of Gata2-Deficiency Associated Childhood Myelodysplastic Syndrome, Case Report and Review of Literature JO - VL - 35 IS - 5 SP - EP - PY - 2025 ER -

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