Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Prevalence of Hsv-1/Hsv-2 and Cmv Infections in Infertile Men and Their Impact on Sperm Parameters: A Cross-Sectional Study in Iran Publisher



Salar SM1 ; Edalat F2 ; Letafati A3, 4 ; Kalantar SM5 ; Javanmardi F6 ; Najafi A7 ; Vakili M8 ; Moattari A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Autophagy Research Center, Shiraz University of Medical Science, Shiraz, Iran
  3. 3. Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Clinical Virology, Tehran University of Medical Science, Tehran, Iran
  5. 5. Reproductive & Genetic Unit, Recurrent Abortion Research Center, Yazd Reproductive Science Institute, Yazd University of Medical Sciences, Yazd, Iran
  6. 6. Department of Biostatistics, Shiraz University of Medical Sciences, Shiraz, Iran
  7. 7. Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  8. 8. Health Monitoring Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Source: Health Science Reports Published:2025


Abstract

Background and Aims: Viral infections are significant contributors to infertility. This study aimed to determine the prevalence of Herpes Simplex Virus 1 and 2 (HSV-1/HSV-2) and cytomegalovirus (CMV) infections in men with infertility, compared to a control group of fertile men. Methods: A cross-sectional study was conducted with seminal fluid samples from 100 fertile and 100 infertile men, aged 20–40 years, referred to Yazd Infertility Center. DNA extraction was done using the AmpliSens kit, and the presence of CMV and HSV-1/HSV-2 was determined via real-time PCR. Sperm parameters (count, quick & slow, motility, morphology, and volume) were also assessed and compared to the control group. Results: CMV infection was found in 16% of fertile and 10% of infertile men. HSV-1/HSV-2 prevalence was significantly higher in infertile men (32%) compared to fertile men (8%). Abnormal sperm count was significantly associated with HSV status (p = 0.001), as was abnormal morphology (p = 0.021), while abnormal quick & slow, motility and volume showed no significant association. Data analysis indicated no correlation between sperm parameters—including sperm quick & slow, motility, count, morphology, and semen volume—and CMV infection. Conclusion: HSV infection is linked to sperm-specific parameters, particularly count and morphology. These findings enhance our understanding of viral-induced male infertility and underscore the need for targeted approaches to manage HSV-1/HSV-2-related infertility. © 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
Related Docs
1. Molecular Detection of Hhv1-5, Aav and Hpv in Semen Specimens and Their Impact on Male Fertility, Human Fertility (2019)
2. Affected Host Cells in Male Reproductive Tissue and Relevant Signaling Pathways Associated With Sars-Cov-2 Infection; [Sars-Cov-2 سلولهای میزبان متاثر در بافتهای تولید مثلی مردانه و مسیرهای سیگنالدهی مرتبط با عفونت], Journal of Isfahan Medical School (2024)
3. Evaluation of Female Infertility and Viral Diseases: A Systematic Review of Coronaviruses, Sexuality and Disability (2024)
Experts (# of related papers)
View all Related Experts
Nazanin Zahra Shafiei Jandaghi (1)
Farhad Rezaei (1)