Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies

Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies Publisher

Mirzaei A¹ ; Jalilian AR¹ ; Shabani G¹ ; Fakhari A² ; Akhlaghi M³ ; Beiki D³

Show Affiliations

1. Nuclear Science and Technology Research Institute, Tehran, 141551339, Iran
2. Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2016

Abstract

In this work development of 68Ga-ethyl cysteinate dimer (68Ga-ECD) a 68Ga tracer for possible cerebral blood flow based on 99mTc ECD homolog is reported. 68Ga-ECD was prepared using generator-based 68GaCl3 and ECD at optimized conditions. Quality control, stability, partition co-efficient and the biodistribution of the tracer (by tissue counting and PET/CT in rats) was studied. Significant metabolism of the lipophilic tracer into water soluble metabolite(s) led to urinary excretion of the tracer, un-comparable to that of homologous 99mTc-compound. Cardiac uptake of the complex suggests formation of a possible lipophil cationic complex and/or metabolite. © 2015, Akademiai Kiado, Budapest, Hungary.

Style	Citing Format
MLA	Mirzaei A, et al.. "Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies." Journal of Radioanalytical and Nuclear Chemistry, vol. 307, no. 1, 2016, pp. 725-732.
APA	Mirzaei A, Jalilian AR, Shabani G, Fakhari A, Akhlaghi M, Beiki D (2016). Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies. Journal of Radioanalytical and Nuclear Chemistry, 307(1), 725-732.
Chicago	Mirzaei A, Jalilian AR, Shabani G, Fakhari A, Akhlaghi M, Beiki D. "Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies." Journal of Radioanalytical and Nuclear Chemistry 307, no. 1 (2016): 725-732.
Harvard	Mirzaei A et al. (2016) 'Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies', Journal of Radioanalytical and Nuclear Chemistry, 307(1), pp. 725-732.
Vancouver	Mirzaei A, Jalilian AR, Shabani G, Fakhari A, Akhlaghi M, Beiki D. Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies. Journal of Radioanalytical and Nuclear Chemistry. 2016;307(1):725-732.
BibTex	@article{ author = {Mirzaei A and Jalilian AR and Shabani G and Fakhari A and Akhlaghi M and Beiki D}, title = {Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies}, journal = {Journal of Radioanalytical and Nuclear Chemistry}, volume = {307}, number = {1}, pages = {725-732}, year = {2016} }
RIS	TY - JOUR AU - Mirzaei A AU - Jalilian AR AU - Shabani G AU - Fakhari A AU - Akhlaghi M AU - Beiki D TI - Development of 68Ga Ethyl Cysteinate Dimer for Pet Studies JO - Journal of Radioanalytical and Nuclear Chemistry VL - 307 IS - 1 SP - 725 EP - 732 PY - 2016 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract