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Plskb: An Interactive Knowledge Base to Support Diagnosis, Treatment, and Screening of Lynch Syndrome on the Basis of Precision Oncology Publisher Pubmed



Dehghani Soufi M1 ; Shirkoohi R2, 3 ; Sanaat Z4 ; Torkamannia A1 ; Hashemi M5 ; Jahandarlashaki S6 ; Yousefpour Marzbali M7 ; Vaez Y4 ; Ferdousi R1
Authors
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Authors Affiliations
  1. 1. Department of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Cancer Research Center, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. BESTforPM, Biomarker Evaluation and Supervision Team for Personalized Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Aix-Marseille Universite, Faculte de Medecine de la Timone, Marseille, France
  6. 6. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Research Center for Immunodeficiency, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: JCO Clinical Cancer Informatics Published:2025


Abstract

PURPOSEUnderstanding the genetic heterogeneity of Lynch syndrome (LS) cancers has led to significant scientific advancements. However, these findings are widely dispersed across various resources, making it difficult for clinicians and researchers to stay informed. Furthermore, the uneven quality of studies and the lack of effective translation of knowledge into clinical practice create challenges in delivering optimal patient care. To address these issues, we developed and launched the Precision Lynch Syndrome Knowledge Base (PLSKB), a specialized, interactive web-based platform that consolidates comprehensive information on LS.METHODSTo create the PLSKB, we conducted an extensive literature review and gathered data from reliable sources. Through an extensive literature review and survey of other reliable sources, we have extracted prominent and relevant content with a high level of accuracy, transparency, and detailed provenance. To enhance usability, we implemented an evidence-leveling framework, categorizing studies on the basis of the type of research, reliability, and applicability to clinical care. The platform is designed to be dynamic, with updates performed monthly to incorporate the latest research.RESULTSThe PLSKB integrates a broad spectrum of data related to LS, including biomarkers, cancer types, screening and prevention strategies, diagnostic methods, and therapeutics options. This centralized resource is intended to support clinicians and researchers in making evidence-based decisions throughout surveillance and care processes. Its interactive design and frequent updates ensure that users have access to the most current and relevant findings.CONCLUSIONThe PLSKB bridges the gap between research and clinical practice by offering a reliable, up-to-date repository of evidence-based information. This tool empowers clinicians and researchers to deliver precision care and advance research for LS and related conditions, ultimately improving patient outcomes. © American Society of Clinical Oncology.
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