Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population

Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population Publisher Pubmed

Saremi L¹ ; Lotfipanah S¹ ; Mohammadi M² ; Hosseinzadeh H³ ; Sayad A⁴ ; Saltanatpour Z⁵

Show Affiliations

1. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2. Baqiyatallah University of Medical Sciences, Tehran, Iran
3. Department of Biology, Faculty of Science, Yazd University, Yazd, Iran
4. Department of Medical Genetics, Shahid Beheshti University of Medical Science, Tehran, Iran
5. Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Cellular and Molecular Biology Published:2016

Abstract

To determine whether the HFE gene variants H63D and C282Y are associated with NAFLD in persons with type 2 diabetes, we conducted a case-control study including 145 case of NAFLD patients with a history of type 2 diabetes and 145 matching control. The genomic DNA was extracted from the peripheral venous blood and the genotyping of HFE gene mutations was analyzed using the PCR-RFLP technique. Statistical analysis was performed using SPSS 12.0 software by χ2 test, t test and ANOVA (P < 0.05). Data showed no increased frequency of HFE mutations in persons with type 2 diabetes and no association between H63D mutation and NAFLD in the study population. Also, we analyzed index of physiological variables including FBS, lipid profile (TC, TG, LDL-C, and HDL-C), BMI, HbA1c, and micro albuminuria and Cr levels). Data showed there are no relationship between these indexes and HFE gene mutations and either NAFLD as a complication of diabetes. But our results showed a relationship between C282Y mutation and NAFLD in persons with type 2 diabetes. C282Y mutation might be a genetic marker of NAFLD in Iranian population. © 2016 by the C.M.B. Association. All rights reserved.

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Style	Citing Format
MLA	Saremi L, et al.. "Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population." Cellular and Molecular Biology, vol. 62, no. 12, 2016, pp. 123-128.
APA	Saremi L, Lotfipanah S, Mohammadi M, Hosseinzadeh H, Sayad A, Saltanatpour Z (2016). Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population. Cellular and Molecular Biology, 62(12), 123-128.
Chicago	Saremi L, Lotfipanah S, Mohammadi M, Hosseinzadeh H, Sayad A, Saltanatpour Z. "Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population." Cellular and Molecular Biology 62, no. 12 (2016): 123-128.
Harvard	Saremi L et al. (2016) 'Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population', Cellular and Molecular Biology, 62(12), pp. 123-128.
Vancouver	Saremi L, Lotfipanah S, Mohammadi M, Hosseinzadeh H, Sayad A, Saltanatpour Z. Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population. Cellular and Molecular Biology. 2016;62(12):123-128.
BibTex	@article{ author = {Saremi L and Lotfipanah S and Mohammadi M and Hosseinzadeh H and Sayad A and Saltanatpour Z}, title = {Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population}, journal = {Cellular and Molecular Biology}, volume = {62}, number = {12}, pages = {123-128}, year = {2016} }
RIS	TY - JOUR AU - Saremi L AU - Lotfipanah S AU - Mohammadi M AU - Hosseinzadeh H AU - Sayad A AU - Saltanatpour Z TI - Association of Hfe Gene Mutations With Nonalcoholic Fatty Liver Disease in the Iranian Population JO - Cellular and Molecular Biology VL - 62 IS - 12 SP - 123 EP - 128 PY - 2016 ER -

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