Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report

Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report Publisher

Norooznezhad AH¹ ; Yarani R¹ ; Payandeh M^{1, 2} ; Hoseinkhani Z¹ ; Mahmoudi H³ ; Kiani S¹ ; Mansouri K¹

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1. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2. Bone Marrow Transplantation Department, School of Medicine, University of Medical Sciences, Kermanshah, Kermanshah, Iran
3. Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Heliyon Published:2023

Abstract

Introduction: Cancer is among the leading causes of death worldwide and affects a considerable number of individuals. Chemotherapy is one the most common treatment for this condition and hair loss is among one of the most prevalent side effects. In this study, we report successful treatment of a patient suffering from persistent chemotherapy-induced alopecia (PCIA) with extracellular enriched vesicles (EVs) derived from human placental mesenchymal stromal cells (MSCs). Case presentation: The patient was a 36-year-old woman with a history of invasive ductal carcinoma, underwent six courses of chemotherapy with paclitaxel and adriamycin. Following this treatment and for almost 18 months, she, unfortunately, had no regrowth of hair except some light vellus hairs on the scalp. She then received MSC-derived EVs with scalp injection (subcutaneous) every 4 weeks for 3 continuous months at which point she presented complete regrowth of terminal hair on her scalp. Conclusion: This report demonstrates that MSC-derived EVs could be a possible treatment for permanent chemotherapy-induced alopecia; however, further studies and trials are necessary. © 2023

Style	Citing Format
MLA	Norooznezhad AH, et al.. "Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report." Heliyon, vol. 9, no. 4, 2023, pp. -.
APA	Norooznezhad AH, Yarani R, Payandeh M, Hoseinkhani Z, Mahmoudi H, Kiani S, Mansouri K (2023). Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report. Heliyon, 9(4), -.
Chicago	Norooznezhad AH, Yarani R, Payandeh M, Hoseinkhani Z, Mahmoudi H, Kiani S, Mansouri K. "Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report." Heliyon 9, no. 4 (2023): -.
Harvard	Norooznezhad AH et al. (2023) 'Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report', Heliyon, 9(4), pp. -.
Vancouver	Norooznezhad AH, Yarani R, Payandeh M, Hoseinkhani Z, Mahmoudi H, Kiani S, et al.. Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report. Heliyon. 2023;9(4):-.
BibTex	@article{ author = {Norooznezhad AH and Yarani R and Payandeh M and Hoseinkhani Z and Mahmoudi H and Kiani S and Mansouri K}, title = {Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report}, journal = {Heliyon}, volume = {9}, number = {4}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Norooznezhad AH AU - Yarani R AU - Payandeh M AU - Hoseinkhani Z AU - Mahmoudi H AU - Kiani S AU - Mansouri K TI - Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report JO - Heliyon VL - 9 IS - 4 SP - EP - PY - 2023 ER -

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