A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment

A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment Publisher

Paryadzanjani S^{1, 3} ; Mahjoob MJ^{1, 3} ; Amanpour S^{2, 3} ; Kheirbakhsh R² ; Akhoundzadeh MH²

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1. School of Mech. Eng., College of Eng., Univ. of Tehran, Tehran, Iran
2. Cancer Biology Research Center, Tehran University of Medical Sciences, Iran
3. Computational Medicine and Systems Biology Network (CMSBN), Universal Scientific Education and Research Network (USERN), Tehran, Iran

Source: IFAC-PapersOnLine Published:2016

Abstract

Combinations of experimental studies and theoretical models have always played a key role in the clinical development of cancer treatments. In this study, in-vivo experiments are conducted in order to study the effects of DDW on melanoma tumor growth and its pharmacokinetics. Existing mathematical models are then employed to describe the melanoma dynamics and drug effects on the tumor growth. The model includes the tumor growth, chemotherapy, and pharmacokinetics. The model parameters are computed by fitting the mathematical relations to the test data using genetic algorithm (GA). A SDRE (State Dependent Ricatti Equation) based control strategy is then synthetized that leads to promising results. An optimal treatment plan is obtained consisting chemotherapy and DDW as a supplement treatment. © 2016

Style	Citing Format
MLA	Paryadzanjani S, et al.. "A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment." IFAC-PapersOnLine, vol. 49, no. 26, 2016, pp. 277-282.
APA	Paryadzanjani S, Mahjoob MJ, Amanpour S, Kheirbakhsh R, Akhoundzadeh MH (2016). A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment. IFAC-PapersOnLine, 49(26), 277-282.
Chicago	Paryadzanjani S, Mahjoob MJ, Amanpour S, Kheirbakhsh R, Akhoundzadeh MH. "A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment." IFAC-PapersOnLine 49, no. 26 (2016): 277-282.
Harvard	Paryadzanjani S et al. (2016) 'A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment', IFAC-PapersOnLine, 49(26), pp. 277-282.
Vancouver	Paryadzanjani S, Mahjoob MJ, Amanpour S, Kheirbakhsh R, Akhoundzadeh MH. A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment. IFAC-PapersOnLine. 2016;49(26):277-282.
BibTex	@article{ author = {Paryadzanjani S and Mahjoob MJ and Amanpour S and Kheirbakhsh R and Akhoundzadeh MH}, title = {A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment}, journal = {IFAC-PapersOnLine}, volume = {49}, number = {26}, pages = {277-282}, year = {2016} }
RIS	TY - JOUR AU - Paryadzanjani S AU - Mahjoob MJ AU - Amanpour S AU - Kheirbakhsh R AU - Akhoundzadeh MH TI - A Supplemental Treatment for Chemotherapy: Control Simulation Using a Mathematical Model With Estimated Parameters Based on in Vivo Experiment JO - IFAC-PapersOnLine VL - 49 IS - 26 SP - 277 EP - 282 PY - 2016 ER -

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