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Micrornas in Non-Malignant Diseases Publisher



Mirzaei H1 ; Rahimian N2 ; Mirzaei HR3 ; Nahand JS4 ; Hamblin MR5
Authors
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Authors Affiliations
  1. 1. Kashan University of Medical Sciences, Kashan, Iran
  2. 2. Iran University of Medical Sciences (IUMS), Tehran, Iran
  3. 3. Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. University of Johannesburg, Doornfontein, 2028, South Africa

Source: Synthesis Lectures on Biomedical Engineering Published:2022


Abstract

Researchers have continued to explore the functional role of human miRNAs in the wider context of human illnesses other than cancer. However, the correlation of miRNAs with various diseases has proved to be a major undertaking. Moreover, patterns of miRNA expression are often tissue-specific, and in several cases depend on the physiological status of the cells. For instance, one report suggested that the gene expression profile of a non-neuronal cell became more similar to the expression pattern of a neuron after the artificial over-expression of the neuron-specific miR-124 [1]. In addition, specific miRNA expression patterns may be diseasespecific, can therefore be of high prognostic significance. Several miRNAs contribute to vital processes like cell division, cell death, intra-cellular signaling, immunity, cell movement, and cellular metabolism [2]. Hence, it is clear that abnormal expression of miRNAs must influence critical cellular functions, and changes in the miRNAs expression have a crucial part in the disease development. © 2022, Springer Nature Switzerland AG.