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Synthetic Minimal Cells and Their Applications Publisher



Kharrazi AY1 ; Zare A2 ; Chapin N3 ; Ghavami S4 ; Pandi A3
Authors
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Authors Affiliations
  1. 1. Department of Biotechnology, University of Tehran, Tehran, Iran
  2. 2. Department of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biochemistry & Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany
  4. 4. Department of Biology, University of Groningen, Groningen, Netherlands

Source: New Frontiers and Applications of Synthetic Biology Published:2022


Abstract

For many years synthetic biologists have used model organisms for their research or industrial purposes. Utilizing these organisms advanced the field, yet, there is a huge amount of unnecessary complexity that limits their applications. Hence there is a need to develop synthetic cells with minimal complexity, life-like homeostasis, self-maintenance, evolution, and reproduction. This can be done through two approaches: top-down and bottom-up. In the top-down approach, the complexity of model organisms is reduced by the deletion of unnecessary genes and interspaced regions in their genome. In the bottom-up approach, synthetic cell-like systems are constructed from functional modules. In this chapter, we address these approaches and their limitations and applications. © 2022 Elsevier Inc.
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