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Depression After Traumatic Brain Injury: A Systematic Review and Meta-Analysis Publisher Pubmed



Dehbozorgi M1 ; Maghsoudi MR2 ; Rajai S3 ; Mohammadi I3 ; Nejad AR4 ; Rafiei MA3 ; Soltani S3 ; Shafiee A5 ; Bakhtiyari M6
Authors
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Authors Affiliations
  1. 1. The Faculty of Medicine, RWTH Aachen University, Rheinisch-Westfalische Technische Hochschule, Aachen, Germany
  2. 2. Department of Emergency Medicine, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

Source: American Journal of Emergency Medicine Published:2024


Abstract

Background: Traumatic brain injury (TBI) afflicts 69 million individuals annually, resulting in numerous neuropsychiatric sequelae. Here, we investigate the possible relation between TBI and depression. Methods: an online database search of Pubmed, Scopus, and Web of Science was conducted on November 3rd, 2023 for observational studies investigating post-TBI depressive symptoms incidence or comparing the prevalence of depressive symptoms between TBI and non-TBI individuals. Results: a total of 43 studies were included in our review, 15 of which reported novel cases of depressive symptomology post-TBI and 34 of which compared depressive symptoms in TBI participants with non-TBI participants. Our meta-analysis showed an incidence of 13 % among 724,842 TBI participants, and a relative risk of 2.10 when comparing 106,083 TBI patients to 323,666 non-TBI controls. 11 of the 43 included studies were deemed as having a high risk of bias. Sensitivity analysis showed our findings to be robust and no publication bias was detected using Egger's regression test. Conclusion: Individuals suffering from TBI are almost twice as likely to develop depressive symptomology compared to non-TBI individuals. © 2024 Elsevier Inc.
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