Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
The Association Between Baseline Vitamin D Level and Clinical Outcomes in Patients With Covid-19 a 7-Month Follow-Up Cohort Study Publisher



Chichagi F1 ; Hadadi A2 ; Kazemian S1, 3 ; Pazoki M4 ; Kafan S4 ; Moradi Tabriz H5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pulmonary Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Topics in Clinical Nutrition Published:2024


Abstract

Our study aimed to understand the link between baseline vitamin D levels at admission and in-hospital clinical outcome and 7-month all-cause mortality in patients hospitalized with COVID-19. Sixty-three percent of 636 Iranian patients had insufficient 25(OH)vitamin D baseline levels (<30 ng/mL) on admission. All patients were followed for 7 months on average. Insufficient baseline levels of vitamin D were associated with an increased risk of in-hospital mortality (P = .022), 7-month all-cause mortality (P = .047), and multiple-organ damage (P = .035) in patients with COVID-19. No association between other in-hospital complications and 25(OH)vitamin D levels was found. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Related Docs
View other Related Docs
1. Dietary Patterns and Micronutrients in Respiratory Infections Including Covid-19: A Narrative Review, BMC Public Health (2024)
2. Vitamin D Supplementation in Covid-19: A Friend or Foe?, EXCLI Journal (2020)
3. Association of Recent and Long-Term Supplement Intakes With Laboratory Indices in Patients With Covid-19 in Tehran, Iran, During 2020, Frontiers in Nutrition (2022)
4. The Association Between the Level of Serum 25(Oh) Vitamin D, Obesity, and Underlying Diseases With the Risk of Developing Covid-19 Infection: A Case–Control Study of Hospitalized Patients in Tehran, Iran, Journal of Medical Virology (2021)
5. Nutritional Approach for Increasing Public Health During Pandemic of Covid-19: A Comprehensive Review of Antiviral Nutrients and Nutraceuticals, Health Promotion Perspectives (2021)
6. Molecular Mechanisms and Therapeutic Effects of Different Vitamins and Minerals in Covid-19 Patients, Journal of Trace Elements in Medicine and Biology (2022)
7. Immunomodulatory Effects of Vitamin D in Influenza Infection, Current Immunology Reviews (2018)
8. The Interplay Between Vitamin D and Viral Infections, Reviews in Medical Virology (2019)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (3)
Sayed Mahdi Marashi (3)
Other Related Docs
9. Immunomodulatory Actions of Vitamin D in Various Immune-Related Disorders: A Comprehensive Review, Frontiers in Immunology (2023)
10. Vitamin D and Covid-19: From Potential Therapeutic Effects to Unanswered Questions, Reviews in Medical Virology (2021)
11. A Randomized Controlled Trial on the Effect of Vitamin D3 on Inflammation and Cathelicidin Gene Expression in Ulcerative Colitis Patients, Saudi Journal of Gastroenterology (2016)
12. The Biochemical Parameters and Vitamin D Levels in Icu Patients With Covid-19: A Cross-Sectional Study, Endocrine# Metabolic and Immune Disorders - Drug Targets (2021)
13. Micronutrients That Affect Immunosenescence, Advances in Experimental Medicine and Biology (2020)
14. Treatment With 25-Hydroxyvitamin D3 (Calcifediol) Is Associated With a Reduction in the Blood Neutrophil-To-Lymphocyte Ratio Marker of Disease Severity in Hospitalized Patients With Covid-19: A Pilot Multicenter, Randomized, Placebo-Controlled, Double-Blinded Clinical Trial, Endocrine Practice (2021)
15. The Evaluation of Clinical Symptoms and Underlying Factors in Infected Patients With Covid-19, Tehran University Medical Journal (2021)
16. Recent Findings on the Coronavirus Disease 2019 (Covid-19); Immunopathogenesis and Immunotherapeutics, International Immunopharmacology (2020)
17. Cardiovascular Diseases Burden in Covid-19: Systematic Review and Meta-Analysis, American Journal of Emergency Medicine (2021)
18. Harnessing the Fundamental Roles of Vitamins: The Potent Anti-Oxidants in Longevity, Biogerontology (2025)
19. Generalizability Assessment of Covid-19 3D Ct Data for Deep Learning-Based Disease Detection, Computers in Biology and Medicine (2022)
20. Relationship Between Cardiac and Liver Markers With In-Hospital Mortality in Covid-19 Patients, Journal of Iranian Medical Council (2022)
21. Role of Vitamin D in Pathogenesis and Severity of Covid-19 Infection, Archives of Physiology and Biochemistry (2023)
22. Vitamin D Supplementation and Calcium: Many-Faced Gods or Nobody in Fighting Against Corona Virus Disease 2019, Clinical Nutrition ESPEN (2024)
23. Vitamin D Receptor Cdx-2-Dependent Response of Central Obesity to Vitamin D Intake in the Subjects With Type 2 Diabetes: A Randomised Clinical Trial, British Journal of Nutrition (2015)
24. Central Nervous System Manifestations in Covid-19 Patients: A Systematic Review and Meta-Analysis, Brain and Behavior (2021)
25. Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives, Journal of Immunology Research (2022)
26. Lower Urinary Tract Symptoms in Hospitalized Patients With Covid-19, Journal of Iranian Medical Council (2022)
27. Positive Association Between Severity of Covid-19 Infection and Liver Damage: A Systematic Review and Meta-Analysis, Gastroenterology and Hepatology from Bed to Bench (2020)
28. Association of Serum Level of 25-Hydroxy Vitamin D Deficiency and Pulmonary Function in Healthy Individuals, Scientific World Journal (2018)
29. The Association Between Micronutrients and the Sars-Cov-2-Specific Antibodies in Convalescent Patients, Infection (2022)
30. A Review on Currently Available Potential Therapeutic Options for Covid-19, International Journal of General Medicine (2020)
31. Chronic Neurological Diseases and Covid-19: Associations and Considerations, Translational Neuroscience (2020)
32. Association of Vitamin D Receptor Gene Polymorphisms and Clinical/Severe Outcomes of Covid-19 Patients, Infection# Genetics and Evolution (2021)
33. Kidney Diseases and Covid-19 Infection: Causes and Effect, Supportive Therapeutics and Nutritional Perspectives, Heliyon (2021)
34. Relationship Between Vitamin D Status in the First Trimester of the Pregnancy and Gestational Weight Gain: A Mediation Analysis, Archives of Gynecology and Obstetrics (2022)
35. Association of Serum 25-Hydroxyvitamin D Concentration With Anthropometric Measures in Children and Adolescents: The Caspian-V Study, Eating and Weight Disorders (2021)
36. Covid-19 Transmission, Vulnerability, Persistence and Nanotherapy: A Review, Environmental Chemistry Letters (2021)
37. Assessment of the Relationship Between Exposure to Air Pollutants and Covid-19 Pandemic in Tehran City, Iran, Atmospheric Pollution Research (2022)
38. The Coronavirus Disease 2019 and Effect on Liver Function: A Hidden and Vital Interaction Beyond the Respiratory System, Reviews and Research in Medical Microbiology (2022)
39. Association of Clinical Characteristics, Antidiabetic and Cardiovascular Agents With Diabetes Mellitus and Covid-19: A 7-Month Follow-Up Cohort Study, Journal of Diabetes and Metabolic Disorders (2021)
40. Clinical Manifestations of Gastrointestinal Symptoms in Covid-19 Patients: An Integrative Review, Gastroenterology Nursing (2021)
41. Vitamin D Effects on Immune Response Against Covid-19 and Influenza Infection: A Review, Bioactive Compounds in Health and Disease (2020)
42. Prevalence of Vitamin D Deficiency and Its Associated Risk Factors Among Rural Population of the Northern Part of the Persian Gulf, BMC Endocrine Disorders (2021)
43. Review Article: Postmortem Liver Pathology Findings in Patients With Covid-19: A Systematic Review, International Journal of Medical Toxicology and Forensic Medicine (2021)
44. Ebv Infection and Vitamin D in Multiple Sclerosis Patients, Nutrition and Lifestyle in Neurological Autoimmune Diseases: Multiple Sclerosis (2017)
45. Role of Serum Mmp-9 Levels and Vitamin D Receptor Polymorphisms in the Susceptibility to Coronary Artery Disease: An Association Study in Iranian Population, Gene (2017)
46. Vitamin D Deficiency in Chronic Idiopathic Urticaria, Iranian Journal of Allergy# Asthma and Immunology (2015)
47. The Predictive Power of Serum Vitamin D for Poor Outcomes in Covid-19 Patients, Food Science and Nutrition (2021)
48. Effect of Single-Dose Injection of Vitamin D on Immune Cytokines in Ulcerative Colitis Patients: A Randomized Placebo-Controlled Trial, APMIS (2019)
49. Vitamin D Sufficiency, a Serum 25-Hydroxyvitamin D at Least 30 Ng/Ml Reduced Risk for Adverse Clinical Outcomes in Patients With Covid-19 Infection, PLoS ONE (2020)
50. Vitamin D Status As a Predictor for Liver Transplant Outcomes, Scientific Reports (2023)