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Efficacy of Persian Medicine Herbal Formulations (Capsules And Decoction) Compared to Standard Care in Patients With Covid-19, a Multicenter Open-Labeled, Randomized, Controlled Clinical Trial Publisher Pubmed



Karimi M1 ; Zarei A1 ; Soleymani S2 ; Jamalimoghadamsiahkali S3 ; Asadi A4 ; Shati M5 ; Jafari M6 ; Rezadoost H7 ; Kordafshar G1 ; Naghizadeh A1 ; Mardi R1 ; Namiranian P1 ; Khamechi SP1, 8 ; Ansari N9 Show All Authors
Authors
  1. Karimi M1
  2. Zarei A1
  3. Soleymani S2
  4. Jamalimoghadamsiahkali S3
  5. Asadi A4
  6. Shati M5
  7. Jafari M6
  8. Rezadoost H7
  9. Kordafshar G1
  10. Naghizadeh A1
  11. Mardi R1
  12. Namiranian P1
  13. Khamechi SP1, 8
  14. Ansari N9
  15. Adel Mehraban MS1
  16. Aliakbarzadeh H1
  17. Khanavi M10
  18. Esmaealzadeh N2
  19. Moravveji A11
  20. Salahi M12
  21. Khoi M12
  22. Razzaghi R13
  23. Banafshe HR14
  24. Alizadeh M8, 15
  25. Akhbari M1, 8
  26. Atharizadeh M8, 16
  27. Izadikhah A17
  28. Elsagh M18
  29. Hossein Zade Ghahnavieh M17
  30. Eghbalian F19
  31. Vanai A20
  32. Izadi H21
  33. Moravej SAAH18, 19
  34. Jazayeri SF18, 19
  35. Bayat H22
  36. Emadi Koochak H23
  37. Zargaran A2
Show Affiliations
Authors Affiliations
  1. 1. Department of Traditional Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Infectious Diseases, Pakdasht Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Faculty of Medicine, University of Helsinki, Helsinki, Finland
  7. 7. Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
  8. 8. Evidence Based Integrative Medicine Research Center, Kashan University of Medical Sciences, Kashan, Iran
  9. 9. Department of Internal Medicine, School of Medicine, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Pharmacognosy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Social Determinants of Health Research Center, Kashan University of Medical Sciences, Kashan, Iran
  12. 12. Department of Infectious Disease, Isabn-e-Maryam Hospital, Isfahan, Iran
  13. 13. Department of Infectious Disease, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran
  14. 14. Department of Pharmacology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  15. 15. Department of Persian Medicine, School of Persian Medicine, Babol University of Medical Sciences, Babol, Iran
  16. 16. Department of Persian Medicine, School of Persian Medicine, Qom University of Medical Sciences, Qom, Iran
  17. 17. Department of Persian Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  18. 18. Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
  19. 19. Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
  20. 20. Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  21. 21. Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  22. 22. Niak Pharmaceutical Company, Gorgan, Iran
  23. 23. Department of Infectious Disease, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Phytotherapy Research Published:2021


Abstract

Persian medicine has recommended clinical experiences and proper herbal remedies for prevention and treatment of microbial infections and respiratory diseases. An open-label, randomized, controlled, multicenter trial was conducted at five hospitals in Tehran and Isfahan provinces of Iran on 358 hospitalized adult patients. A total of 174 patients received standard care and 184 received herbal remedies (polyherbal decoction every 8 hr and two herbal capsules every 12 hr) plus standard care for 7 days. The primary clinical endpoint was the duration of hospital stay, and secondary outcomes were clinical improvement of symptoms based on self-assessment questionnaire. Results demonstrated that these natural decoction and capsules treatment plus routine care significantly decreased duration of hospital dyspnea (3.291 day vs. 6.468 days), accelerated clinical improvement, and decreased symptoms such as dry cough, dyspnea, muscle pain, headache, fatigue, anorexia, chills, runny nose, sputum cough, and vertigo in the treatment group compared with standard-care group. Significant effects of these polyherbal formulations on improving the symptoms of COVID-19 could be incredibly promising for managing this pandemic with acceptable tolerability. © 2021 John Wiley & Sons Ltd.
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