A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study

A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study Publisher Pubmed

Bahreini M¹ ; Hosseinzadegan A² ; Rashidi A³ ; Miri SR⁴ ; Mirzaei HR⁵ ; Hajian P⁵

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1. Hazrat-e Masoumeh University, Qom, Iran
2. Laser and Plasma Research Institute, Shahid Beheshti University, Tehran, Iran
3. Clinical Pathology Laboratory, Shohadae Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Cancer Research Center, Shohadae Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Talanta Published:2019

Abstract

The importance of blood serum testing in most medical diagnosis has led researchers to seek for a reliable analysis method. Raman spectroscopy is a potential tool for probing serum components due to its real-time and non-destructive measurements without need to any additional reagents. So, Raman spectroscopy for the analysis and discrimination of human serum of healthy and gastric cancer subjects is investigated in this work. In order to find the correlation between Raman spectra and enzymatic test results of glucose, cholesterol, HDL, LDL and triglycerides of serum samples, the partial least squares regression (PLSR) method is utilized. Moreover, the Raman spectroscopy is used to distinguish between serum samples of healthy people and gastric cancer patients using partial least square discriminant analysis (PLS-DA) method. Correlation results reveal that for all serum components, the correlation coefficients between Raman spectra and all enzymatic test results are above 94% significantly. Discrimination results of healthy subjects and gastric cancer patients show that 87.5 ± 2.5% of healthy and gastric cancer subjects are diagnosed properly. Our preliminary results can confirm the Raman method in analysis of serum and also as a diagnostic tool in screening of gastric cancer. © 2019

Style	Citing Format
MLA	Bahreini M, et al.. "A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study." Talanta, vol. 204, no. , 2019, pp. 826-832.
APA	Bahreini M, Hosseinzadegan A, Rashidi A, Miri SR, Mirzaei HR, Hajian P (2019). A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study. Talanta, 204(), 826-832.
Chicago	Bahreini M, Hosseinzadegan A, Rashidi A, Miri SR, Mirzaei HR, Hajian P. "A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study." Talanta 204, no. (2019): 826-832.
Harvard	Bahreini M et al. (2019) 'A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study', Talanta, 204(), pp. 826-832.
Vancouver	Bahreini M, Hosseinzadegan A, Rashidi A, Miri SR, Mirzaei HR, Hajian P. A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study. Talanta. 2019;204():826-832.
BibTex	@article{ author = {Bahreini M and Hosseinzadegan A and Rashidi A and Miri SR and Mirzaei HR and Hajian P}, title = {A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study}, journal = {Talanta}, volume = {204}, number = {}, pages = {826-832}, year = {2019} }
RIS	TY - JOUR AU - Bahreini M AU - Hosseinzadegan A AU - Rashidi A AU - Miri SR AU - Mirzaei HR AU - Hajian P TI - A Raman-Based Serum Constituents’ Analysis for Gastric Cancer Diagnosis: In Vitro Study JO - Talanta VL - 204 IS - SP - 826 EP - 832 PY - 2019 ER -

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