Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study

Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study Publisher Pubmed

Ulutas S ; Sucu D H ; Uluduz E ; Unal Cevik I ; Tur E K ; Gursoy G ; Genc H ; Ak A K ; Karadas O ; Polat B ; Karaci R ; Sahbaz F G ; Sirin T C ; Alis C Show All Authors

Ulutas S
Sucu D H
Uluduz E
Unal Cevik I
Tur E K
Gursoy G
Genc H
Ak A K
Karadas O
Polat B
Karaci R
Sahbaz F G
Sirin T C
Alis C
Ari B C
Tepe N
Hasirci Bayir B R
Acir I
Demirel E A
Vuralli D
Arvaniti C
Dikmen P Y
Togha M
Mercan O
Gurel G
Guerrero A L
Nezir G
Atalar A C
Saracoglu T T
Cetinkaya Y
Ulusoy E K
Lee M J
Goadsby P J
Oksuz N
Keskin K G
Shafiyev J
Sokmen O
Domac F M
Aydinlar E I
Demir M
Bolay H
Mitsikostas D D
Akturk T
Azorin D G
Yolcu O
Gulec M S
Yayla V
Saritas A S
Yener M O
Puledda F
Eyupoglu S
Tasdelen B
Uluduz D
Ghouri R
Ozge A

Source: Journal of Clinical Neuroscience Published:2026

Abstract

Peripheral nerve blocks (PNBs) represent an accessible, minimally invasive therapeutic approach for headache disorders; however, real-world data on procedural patterns and outcomes in different headache subtypes remain limited. This multicenter study evaluated 2,219 patients (receiving 2250 PNBs) with migraine, tension-type headache (TTH), trigeminal autonomic cephalalgias (TACs), and cranial neuralgias. Demographic features, preventive and acute medicine, target nerves, anaesthetic agents, injection volumes, application intervals, number of sessions, clinical outcomes, and adverse events were analysed. Longitudinal outcomes were assessed with three-level mixed-effects models accounting for repeated visits within patients and patients within centers, using linear mixed models for VAS and cumulative-link mixed models for ordinal headache frequency and analgesic use. Migraine was the predominant diagnosis (77.5%), comprising chronic (55.6%) and episodic (44.4%) forms. Greater occipital nerve block was the dominant procedure in migraine, TTH, and TACs, but was less frequent in neuralgias, both in occipital and trigeminal. Injection volume, application interval, and local anesthetic choice varied by headache type and target nerve. GON volumes were most often 1–2 mL across headache groups, except in neuralgias, where 2–3 mL was most common. PNBs were associated with statistically significant improvements in headache frequency, severity, and duration as well as decrease in analgesic use in all analysed groups and subgroups. Adverse events were uncommon and mainly mild. Intercept-only models indicated modest center-level clustering, with ICCs of 0.093 for VAS scores, 0.134 for headache frequency, and 0.130 for analgesic use. Overall, these findings support PNBs as useful and well-tolerated options while highlighting substantial real-world variation in practice. © 2026 The Author(s).

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Style	Citing Format
MLA	Ulutas S, et al.. "Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study." Journal of Clinical Neuroscience, vol. 153, no. , 2026, pp. -.
APA	Ulutas S, Sucu D H, Uluduz E, Unal Cevik I, Tur E K, Gursoy G, Genc H, Ak A K, Karadas O, Polat B, Karaci R, Sahbaz F G, Sirin T C, Alis C, Ari B C, Tepe N, Hasirci Bayir B R, Acir I, Demirel E A, ... Ozge A (2026). Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study. Journal of Clinical Neuroscience, 153(), -.
Chicago	Ulutas S, Sucu D H, Uluduz E, Unal Cevik I, Tur E K, Gursoy G, Genc H, et al.. "Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study." Journal of Clinical Neuroscience 153, no. (2026): -.
Harvard	Ulutas S et al. (2026) 'Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study', Journal of Clinical Neuroscience, 153(), pp. -.
Vancouver	Ulutas S, Sucu D H, Uluduz E, Unal Cevik I, Tur E K, Gursoy G, et al.. Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study. Journal of Clinical Neuroscience. 2026;153():-.
BibTex	@article{ author = {Ulutas S and Sucu D H and Uluduz E and Unal Cevik I and Tur E K and Gursoy G and Genc H and Ak A K and Karadas O and Polat B and Karaci R and Sahbaz F G and Sirin T C and Alis C and Ari B C and Tepe N and Hasirci Bayir B R and Acir I and Demirel E A and Vuralli D and Arvaniti C and Dikmen P Y and Togha M and Mercan O and Gurel G and Guerrero A L and Nezir G and Atalar A C and Saracoglu T T and Cetinkaya Y and Ulusoy E K and Lee M J and Goadsby P J and Oksuz N and Keskin K G and Shafiyev J and Sokmen O and Domac F M and Aydinlar E I and Demir M and Bolay H and Mitsikostas D D and Akturk T and Azorin D G and Yolcu O and Gulec M S and Yayla V and Saritas A S and Yener M O and Puledda F and Eyupoglu S and Tasdelen B and Uluduz D and Ghouri R and Ozge A}, title = {Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study}, journal = {Journal of Clinical Neuroscience}, volume = {153}, number = {}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Ulutas S AU - Sucu D H AU - Uluduz E AU - Unal Cevik I AU - Tur E K AU - Gursoy G AU - Genc H AU - Ak A K AU - Karadas O AU - Polat B AU - Karaci R AU - Sahbaz F G AU - Sirin T C AU - Alis C AU - Ari B C AU - Tepe N AU - Hasirci Bayir B R AU - Acir I AU - Demirel E A AU - Vuralli D AU - Arvaniti C AU - Dikmen P Y AU - Togha M AU - Mercan O AU - Gurel G AU - Guerrero A L AU - Nezir G AU - Atalar A C AU - Saracoglu T T AU - Cetinkaya Y AU - Ulusoy E K AU - Lee M J AU - Goadsby P J AU - Oksuz N AU - Keskin K G AU - Shafiyev J AU - Sokmen O AU - Domac F M AU - Aydinlar E I AU - Demir M AU - Bolay H AU - Mitsikostas D D AU - Akturk T AU - Azorin D G AU - Yolcu O AU - Gulec M S AU - Yayla V AU - Saritas A S AU - Yener M O AU - Puledda F AU - Eyupoglu S AU - Tasdelen B AU - Uluduz D AU - Ghouri R AU - Ozge A TI - Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study JO - Journal of Clinical Neuroscience VL - 153 IS - SP - EP - PY - 2026 ER -

Style

Citing Format

MLA

Ulutas S, et al.. "Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study." Journal of Clinical Neuroscience, vol. 153, no. , 2026, pp. -.

APA

Ulutas S, Sucu D H, Uluduz E, Unal Cevik I, Tur E K, Gursoy G, Genc H, Ak A K, Karadas O, Polat B, Karaci R, Sahbaz F G, Sirin T C, Alis C, Ari B C, Tepe N, Hasirci Bayir B R, Acir I, Demirel E A, ... Ozge A (2026). Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study. Journal of Clinical Neuroscience, 153(), -.

Chicago

Ulutas S, Sucu D H, Uluduz E, Unal Cevik I, Tur E K, Gursoy G, Genc H, et al.. "Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study." Journal of Clinical Neuroscience 153, no. (2026): -.

Harvard

Ulutas S et al. (2026) 'Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study', Journal of Clinical Neuroscience, 153(), pp. -.

Vancouver

Ulutas S, Sucu D H, Uluduz E, Unal Cevik I, Tur E K, Gursoy G, et al.. Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study. Journal of Clinical Neuroscience. 2026;153():-.

BibTex

@article{ author = {Ulutas S and Sucu D H and Uluduz E and Unal Cevik I and Tur E K and Gursoy G and Genc H and Ak A K and Karadas O and Polat B and Karaci R and Sahbaz F G and Sirin T C and Alis C and Ari B C and Tepe N and Hasirci Bayir B R and Acir I and Demirel E A and Vuralli D and Arvaniti C and Dikmen P Y and Togha M and Mercan O and Gurel G and Guerrero A L and Nezir G and Atalar A C and Saracoglu T T and Cetinkaya Y and Ulusoy E K and Lee M J and Goadsby P J and Oksuz N and Keskin K G and Shafiyev J and Sokmen O and Domac F M and Aydinlar E I and Demir M and Bolay H and Mitsikostas D D and Akturk T and Azorin D G and Yolcu O and Gulec M S and Yayla V and Saritas A S and Yener M O and Puledda F and Eyupoglu S and Tasdelen B and Uluduz D and Ghouri R and Ozge A}, title = {Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study}, journal = {Journal of Clinical Neuroscience}, volume = {153}, number = {}, pages = {-}, year = {2026} }

RIS

TY - JOUR
AU - Ulutas S
AU - Sucu D H
AU - Uluduz E
AU - Unal Cevik I
AU - Tur E K
AU - Gursoy G
AU - Genc H
AU - Ak A K
AU - Karadas O
AU - Polat B
AU - Karaci R
AU - Sahbaz F G
AU - Sirin T C
AU - Alis C
AU - Ari B C
AU - Tepe N
AU - Hasirci Bayir B R
AU - Acir I
AU - Demirel E A
AU - Vuralli D
AU - Arvaniti C
AU - Dikmen P Y
AU - Togha M
AU - Mercan O
AU - Gurel G
AU - Guerrero A L
AU - Nezir G
AU - Atalar A C
AU - Saracoglu T T
AU - Cetinkaya Y
AU - Ulusoy E K
AU - Lee M J
AU - Goadsby P J
AU - Oksuz N
AU - Keskin K G
AU - Shafiyev J
AU - Sokmen O
AU - Domac F M
AU - Aydinlar E I
AU - Demir M
AU - Bolay H
AU - Mitsikostas D D
AU - Akturk T
AU - Azorin D G
AU - Yolcu O
AU - Gulec M S
AU - Yayla V
AU - Saritas A S
AU - Yener M O
AU - Puledda F
AU - Eyupoglu S
AU - Tasdelen B
AU - Uluduz D
AU - Ghouri R
AU - Ozge A
TI - Peripheral Nerve Blocks in Primary Headaches and Neuralgias: A Six-Country Multicenter Real-World Study
JO - Journal of Clinical Neuroscience
VL - 153
IS -
SP -
EP -
PY - 2026
ER -

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