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Circulating Endocannabinoid Levels in Pregnant Women With Gestational Diabetes Mellitus: A Case–Control Study Publisher Pubmed



Bazyar H1, 2, 4 ; Nasiri K3 ; Ghanbari P2, 4 ; Mohammadi E5 ; Yagin NL6 ; Khazdouz M7 ; Aghamohammadi V5 ; Asgarzadeh SA8
Authors
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Authors Affiliations
  1. 1. Sirjan School of Medical Sciences, Sirjan, Iran
  2. 2. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Nursing, Khalkhal University of Medical Sciences, Khalkhal, Iran
  4. 4. Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  5. 5. Department of Nutrition, Khalkhal University of Medical Sciences, Khalkhal, Iran
  6. 6. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran

Source: BMC Endocrine Disorders Published:2022


Abstract

Background: The role of the Endocannabinoids (ECs) in insulin resistance, and their association with visceral obesity and metabolic profile have been studied extensively. Since the association between ECs and metabolic factors in Gestational Diabetes Mellitus (GDM) are not clear, we aimed to evaluate the levels of N-Arachidonoylethanolamide (AEA) and 2-Arachidonoylglycerol (2-AG) and their association with C-reactive protein (CRP), glycemic indices, blood pressure, and anthropometric indices in pregnant women with GDM. Methods: The present case–control study was conducted among 96 singleton pregnant women aged 18–40 years, including 48 healthy pregnant women (control group) and 48 women with a positive diagnosis of GDM (case group). Odds Ratios (ORs) and 95% Confidence Intervals (CIs) for GDM were checked according to endocannabinoids and anthropometric indices using Multivariable Logistic Regression. Results: AEA was significantly associated with increased risk of GDM in models 1, 2 and 3 (OR = 1.22, 95% CI: 1.06–1.41; OR = 1.54, 95% CI: 1.19–1.97; OR = 1.46, 95% CI:1.11–1.91). A positive but no significant association was found for AEA in model 4 (OR = 1.38,95% CI: 0.99–1.92). Similar to AEA, 2-AG was also positively associated with the likelihood of GDM in Models 1, 2, and 3 but the association attenuated to null in model 4 (OR = 1.25; 95% CI: 0.94- 1.65). Conclusions: Our findings showed that levels of ECs were significantly higher in pregnant women with GDM compared to healthy ones. Also, ECs levels were associated with the likelihood of GDM, independent of BMI and weight gain. © 2022, The Author(s).
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