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Evaluation of 153Sm/177Lu-Edtmp Mixture in Wild-Type Rodents As a Novel Combined Palliative Treatment of Bone Pain Agent Publisher



Ranjbar H1 ; Bahramisamani A1 ; Beiki D2 ; Shirvaniarani S1 ; Ghannadimaragheh M1
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Authors Affiliations
  1. 1. Radiopharmaceutical Research and Development Lab (RRDL), Nuclear Science and Technology Research Institute (NSTRI), P.O. Box 14395-836, Tehran, Iran
  2. 2. Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Radioanalytical and Nuclear Chemistry Published:2015


Abstract

In this work, the cocktail complex 153Sm/177Lu-EDTMP was prepared in high radiochemical purity (more than 99 %) using in house synthesized EDTMP ligand for obtaining a possible synergistic wide range palliative agent. The mixture was administered to wild-type rats and biodistribution data collected after 2 h to 7 days showed at least 70 % accumulation of the radioactivity in the bone tissues. Scintigraphic images were taken from wild-type rats injected with 153Sm/177Lu-EDTMP after 24 h and the biodistribution was shown to be consistent with post-mortem data. A comparative accumulation study was performed for vital organs up to 7 days. 153Sm/177Lu-EDTMP seemed a promising agent for bone pain palliation therapy in skeletal metastases in humans as a novel combined radiopharmaceutical. © 2014, Akademiai Kiado, Budapest, Hungary.
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