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Adverse Drug Reactions of Multiple Sclerosis Diseasemodifying Drugs Publisher



Salehbayat M1 ; Abolfazli R2 ; Mohebbi N3, 4 ; Savar SM4 ; Shalviri G4 ; Gholami K3, 4
Authors
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Authors Affiliations
  1. 1. School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Neurology, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Pharmacy, Rational Use of Drugs Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran

Source: Basic and Clinical Neuroscience Published:2023


Abstract

Introduction: High frequency of adverse drug reactions (ADRs) challenges multiple sclerosis (MS) treatment. This study aims to assess the nature and frequency of ADRs induced by MS medications in an observational cross-sectional study. Methods: ADRs of all outpatients who had seen a neurologist and had received at least one disease-modifying therapy (DMT) for MS during the last three months were investigated. Results: A total of 484 ADRs were detected in these patients. The preventability rate was 5.9%, and 0.61% of reactions were serious. Conclusion: The high frequency of adverse drug reactions in this study shows a strong need for strategy planning to increase patients’ adherence to treatment. © 2023 Iran University of Medical Sciences. All rights reserved.