Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Response to Neoadjuvant Chemotherapy in Locally Advanced Gastric and Gastroesophageal Cancer: Phase Ii Clinical Trial



Samiei F1 ; Maddah Safaei A1 ; Esmati E1 ; Alibakhshi A1 ; Mirai Ashtiani MS1 ; Haddad P1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital, Tehran, Iran

Source: International Journal of Radiation Research Published:2015

Abstract

Background: Gastric cancer is an important health problem across the world. Chemotherapy in combination with local treatment is standard treatment for locally advanced gastroesophageal cancers. The purpose of this investigation was evaluation of response and tolerability to neoadjuvant EOX regimen in locoregionally advanced gastric cancer. Materials and Methods: patients with locoregionally advanced gastric or EG junction adenocarcinoma enrolled in this study. Staging workup including chest and abdominal computed tomography (CT) scan, upper GI endoscopy, endoscopic ultrasonography (EUS), CEA, CBC, liver and renal function test were done. A)er treatment with 3 cycles of EOX regimen, endoscopic ultrasonography (EUS) and chest and abdominal CT scan was done to evaluate the response to neoadjuant chemotherapy. Results: The age of patients ranged from 37 to 78 years, with a mean age of 56.6 (SD=11.8). before chemotherapy, most patients were classified as stage III (98.8%) and a)er chemotherapy, most patients were classified as stage II (57.14%). only 28.5% of tumors were resectable before chemotherapy, but a)er chemotherapy 82.1% of tumors were resectable. 75% of tumors were downstaged a)er chemotherapy. Conclusion: With regard to acceptable response and downstaging of tumors and less toxicity with EOX regimen in locoregionally advanced gastric cancer, it seems that evaluation of this regimen as neoadjuvant chemotherapy in more advanced phase III clinical trial is necessary and logical.