The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats

The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats Publisher Pubmed

Meamar M¹ ; Dehpour T² ; Mazloom R¹ ; Sharifi F¹ ; Raoufy MR¹ ; Dehpour AR² ; Mani AR^{1, 2}

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1. Department of Physiology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
2. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Autonomic Neuroscience: Basic and Clinical Published:2015

Abstract

The effect of endotoxin on heart rate variability (HRV) was assessed in diabetic and controls rats using a telemetric system. Endotoxin induced a reduction in sample entropy of cardiac rhythm in control animals. However, this effect was significantly blunted in streptozotocin-induced diabetic rats. Since uncoupling of cardiac pacemaker from cholinergic control is linked to reduced HRV in endotoxemia, chronotropic responsiveness to cholinergic stimulation was assessed in isolated atria. Endotoxemia was associated with impaired responsiveness to carbacholine in control rats. However, endotoxemia did not impair cholinergic responsiveness in diabetic atria. These findings corroborates with development of endotoxin tolerance in diabetic rats. © 2014 Elsevier B.V.

2. Licofelone, a Dual Cyclooxygenase/5-Lipoxygenase Inhibitor, Reverses Endotoxin-Induced Impaired Atrial Chronotropic Responsiveness to Cholinergic Stimulation in Rats, European Journal of Pharmacology (2020)

Experts (# of related papers)

Ahmad Reza Dehpour (2)

Farahnaz Jazaeri Jooneghani (1)

Style	Citing Format
MLA	Meamar M, et al.. "The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats." Autonomic Neuroscience: Basic and Clinical, vol. 189, no. , 2015, pp. 83-86.
APA	Meamar M, Dehpour T, Mazloom R, Sharifi F, Raoufy MR, Dehpour AR, Mani AR (2015). The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats. Autonomic Neuroscience: Basic and Clinical, 189(), 83-86.
Chicago	Meamar M, Dehpour T, Mazloom R, Sharifi F, Raoufy MR, Dehpour AR, Mani AR. "The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats." Autonomic Neuroscience: Basic and Clinical 189, no. (2015): 83-86.
Harvard	Meamar M et al. (2015) 'The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats', Autonomic Neuroscience: Basic and Clinical, 189(), pp. 83-86.
Vancouver	Meamar M, Dehpour T, Mazloom R, Sharifi F, Raoufy MR, Dehpour AR, et al.. The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats. Autonomic Neuroscience: Basic and Clinical. 2015;189():83-86.
BibTex	@article{ author = {Meamar M and Dehpour T and Mazloom R and Sharifi F and Raoufy MR and Dehpour AR and Mani AR}, title = {The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats}, journal = {Autonomic Neuroscience: Basic and Clinical}, volume = {189}, number = {}, pages = {83-86}, year = {2015} }
RIS	TY - JOUR AU - Meamar M AU - Dehpour T AU - Mazloom R AU - Sharifi F AU - Raoufy MR AU - Dehpour AR AU - Mani AR TI - The Effect of Endotoxin on Heart Rate Dynamics in Diabetic Rats JO - Autonomic Neuroscience: Basic and Clinical VL - 189 IS - SP - 83 EP - 86 PY - 2015 ER -

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