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Interleukin 9 Serum Level and Single Nucleotide Polymorphism in Patients With Asthma Publisher Pubmed



Mahdaviani SA1 ; Eskian M2, 3 ; Khorasanizadeh M2, 3 ; Bashardoost B4 ; Nejad ST1 ; Jamaati H5 ; Rezaei A2 ; Sadr M2, 6 ; Aryan Z2, 6 ; Rezaei N2, 3, 7, 8, 9
Authors
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Authors Affiliations
  1. 1. Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmu-nity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Pediatric department of Bou-Ali Hospital, Ardebil University of Medical Sciences, Ardebil, Iran
  5. 5. Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  7. 7. Pediatric Respiratory Diseases Education and Research Network (PRDERN), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  8. 8. Molecular Immunology Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Acta Biomedica Published:2021


Abstract

Background: Asthma is a chronic inflammatory disease of airways which accounts for a huge eco-nomic, morbidity, and mortality burden. There are different cytokines that contribute to asthma pathophysiol-ogy. Learning about these cytokines leads to attaining novel anti-inflammatory treatments for asthma control. Objectives: The objective of this study is to investigate the association between interleukin-9 serum level and gene polymorphism with asthma susceptibility. Methods: This was a case-control study of 70 asthmatic patients and 77 healthy control adults aged 18-60. Asthma diagnosis and severity were based on physician diagnosis, pulmonary function test (PFT) and 2016 guild line of Global Initiative for Asthma (GINA). Interleukin 9(IL-9) serum level was measured using sandwich enzyme linked immunosorbent assay. IL9 promoter single nucleotide polymorphism (SNP) (rs2069882) was also assessed using Real-Time PCR Sys-tem. Results: There was no significant association between IL-9 SNP polymorphism and asthma. IL-9 serum level was significantly associated with asthma susceptibility (p value= 0.016) and absolute eosinophil count (AEC) (P value=0.033) however, its correlation with atopic asthma type, asthma severity and Immunoglubin E serum level were not statistically significant. Conclusion: Although there was no association between IL-9 SNP and asthma, but IL-9 serum level was significantly correlated with asthma susceptibility and AEC. (www.actabiomedica.it). © Mattioli 1885.
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