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Local Ocular Safety of the Subconjunctival Injection of Cetuximab in Rabbits Publisher Pubmed



Aghaei H1 ; Kheirkhah A2 ; Alizadeh AM3 ; Eshaghi A1 ; Aliakbarnavahi R1 ; Keikha Z4 ; Chaibakhsh S1
Authors
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Authors Affiliations
  1. 1. Eye Research Center, The Five Senses Health Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Ophthalmology, Long School of Medicine, UT Health San Antonio, San Antonio, TX, United States
  3. 3. Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Ophthalmology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Source: BMC Ophthalmology Published:2023


Abstract

Background: To evaluate the safety of different doses of subconjunctival cetuximab in rabbits. Methods: After general anesthesia rabbits received a subconjunctival injection of 2.5 mg in 0.5 ml, 5 mg in 1 ml, and 10 mg in 2 ml of cetuximab in their right eyes (two rabbits in each group). A similar volume of normal saline solution was injected subconjunctivally in the left eyes. The histopathologic changes were evaluated after enucleation with the aid of H&E staining. Results: No significant difference were observed between the treated and control eyes in terms of conjunctival inflammation, goblet cell density, or limbal blood vessel density for all administered doses of cetuximab. Conclusion: Subconjunctival injection of cetuximab with the administrated doses in rabbit eyes are safe. © 2023, The Author(s).
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