Multiple Sclerosis As a Moderator in the Dynamics of Interoceptive Awareness and Emotion Dysregulation Publisher



Melhi E¹ ; Zarani F¹ ; Panaghi L² ; Harirchian MH³ Show Affiliations
Source: Journal of Research and Health Published:2025

Abstract

Background: Suffering from multiple sclerosis (MS) appears to have ramifications not only for emotional well-being and emotion regulation but also for interoceptive awareness and its constituent elements. This study aimed to assess the intricate interplay between interoceptive awareness and emotion dysregulation, with a particular emphasis on the potential moderating influence of MS. Methods: The population of this cross-sectional study consisted of all MS patients and their healthy caregivers and/or companions who visited MS clinics at Emam Khomeini and Sina Hospitals in Tehran. Utilizing purposive sampling based on inclusion criteria, a sample of 429 individuals was selected, comprising 161 relapsing-remitting MS (RRMS) patients and 268 healthy individuals. Data analysis was conducted using descriptive statistics and hierarchical regression analysis subsequent to the completion of the multidimensional assessment of interoceptive awareness version-2 (MAIA-2) and the difficulties in emotion regulation scale (DERS). Results: The results revealed a significant and negative association between all facets of interoceptive awareness and emotional regulation challenges for both MS patients and healthy individuals (r=-0.12 to-0.54, P<0.05). Notably, the moderating impact of MS on this relationship exhibited variations across the MAIA-2 subscales (P<0.05). Conclusion: In addition to unraveling the complex interaction between interoception and emotion regulation in MS, these findings regarding the possible role of interoceptive awareness in emotional well-being could benefit clinicians, especially those who work with the mental health of individuals with MS. © 2025 The Author(s).