Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Differential Gene Expression of Bcl-2, Zeb2‑As1 and Balr-2 in Prostate Cancer and Benign Prostatic Hyperplasia Publisher Pubmed



Ahani M1, 2 ; Ghaderian SMH2, 3 ; Mehr Azma M4 ; Kamali K5 ; Naghavi Gargari B6 ; Bahramali G7 ; Akbarzadeh R8, 9
Authors
Show Affiliations
Authors Affiliations
  1. 1. Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Aliasghar Children's Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Urology, Hasheminejad Hospital, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Basic Sciences, Faculty of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  7. 7. Hepatitis, AIDS and Bloodborne Diseases Department, Pasteur Institute of Iran, Tehran, Iran
  8. 8. Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
  9. 9. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Andrologia Published:2022


Abstract

Prostate cancer (PCa) and benign prostate hyperplasia (BPH) are highly prevalent heterogeneous disorders among men. Whereas PCa and BPH underline common pathological features, apoptotic-related genes might be differentially expressed in these diseases. This study was aimed at testing BCL-2 as well as BALR-2 and ZEB2‑AS1 apoptosis-related long non-coding RNA (lncRNA) in patients with PCa and BPH. The expression levels of the BCL-2 gene and ZEB2-AS1 lncRNA were upregulated in tumoural tissues in comparison to adjacent non-cancerous tissues (ANCTs) and BPH tissues. In contrast, the expression level of BALR-2 lncRNA was significantly higher in BPH compared with tumoural tissues. Furthermore, while no association was noticed between the relative expression of ZEB2-AS1 and the tumour grade, the relative expression of BCL-2 and BALR-2 is strongly associated with a higher grade of the tumour in PCa samples compared with the ANCTs. The receiver operating characteristic (ROC) curve analysis indicated the highest specificity and diagnostic value in distinguishing PCa and ANCTs as well as PCa and BPH, respectively. In conclusion, altered expression of BCL-2 and BALR-2 was observed to be associated with tumoural progression and could be used as potential candidates for distinguishing PCa tissues from ANCTs or BPH samples. © 2021 Wiley-VCH GmbH.
Related Docs
1. Association of Stat3, Ptprt, Tnk2-As1, Linc-Ror Genes Expression Level With Prostate Cancer and Benign Prostatic Hyperplasia, International Journal of Cancer Management (2022)
2. An Overview of Long Noncoding Rnas: Biology, Functions, Therapeutics, Analysis Methods, and Bioinformatics Tools, Cell Biochemistry and Function (2022)
3. Deciphering the Oncogenic Landscape: Unveiling the Molecular Machinery and Clinical Significance of Lncrna Tmpo-As1 in Human Cancers, Pathology Research and Practice (2024)
4. Overexpression of Long Intergenic Noncoding Rnas in Bladder Cancer: A New Insight to Cancer Diagnosis, Pathology Research and Practice (2022)
Experts (# of related papers)
Seyed Hamidollah Ghaffari (1)