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Insulin and Myometrial Contractility; Are There Any Links? a Narrative Review Publisher Pubmed



Ghafourifar P1 ; Farahani Z2 ; Norooznezhad AH3 ; Hantoushzadeh S4 ; Azimzadeh M5 ; Nabavian SM6 ; Behzadian A2 ; Allely QK7
Authors
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Authors Affiliations
  1. 1. Bassett Healthcare Network, New York, United States
  2. 2. Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Vali-E-Asr Reproductive Health Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Putra, Selangor, Malaysia
  6. 6. Department of Obstetrics, Gynecology, and Perinatology, Hamadan University of Medical Sciences, Hamadan, Iran
  7. 7. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Reproductive Biology Published:2025


Abstract

Contrary to the evidence supporting the role for insulin in stimulating uterine contraction, only a limited number of studies have highlighted the inhibitory effect of insulin on myometrial contractions in human and rodent. A hypothetical narrative review of the current literature was conducted, revealing the current literature and shows the potential inhibitory effects of insulin on myometrial contractility. These inhibitory mechanisms include activation of adenylyl cyclase signaling pathways, an increase in cAMP production, a decrease in Ca2 + influx and cytosolic Ca2+, hyperpolarization of the cell membrane, and stimulation of NO synthesis. Altered oxytocin sensitivity, structural similarity to relaxin, modulating abscisic acid (ABA) effect, and synergistic interaction with progesterone, adiponectin, and leptin may also represent additional mechanisms for the inhibitory effects of insulin on myometrial contractions. The literature indicates that insulin exhibits inhibitory effects on myometrial contractility. Confirming such a conclusion through future studies may propose insulin as a possible uterine quiescent. © 2025 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn
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