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Human Toxocariasis in Individuals With Blood Disorders and Cancer Patients: The First Seroepidemiological Study in Iran Publisher



Raissi V1, 2 ; Sohrabi N3 ; Bayat F1 ; Etemadi S4 ; Raiesi O5 ; Jalali P6 ; Karami M7 ; Abdollahi A8 ; Hoseiny Z9 ; Shayanfard M10 ; Alizadeh G1 ; Gadalla ME11 ; Ibrahim A11
Authors
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Authors Affiliations
  1. 1. Department of Medical Parasitology and Mycology, Faculty of public health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Parasitology and Mycology, School of medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Parasitology and Mycology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  5. 5. Department of Parasitology, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran
  6. 6. Department of Microbiology, Tehran Branch, Islamic Azad University, Tehran, Iran
  7. 7. Department of Medical Parasitology and Mycology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  8. 8. Department of Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
  9. 9. Department of Parasitology and Mycology, Hamadan University of Medical Sciences, Hamadan, Iran
  10. 10. Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
  11. 11. Genetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), Sadat City, Egypt

Source: Journal of Parasitic Diseases Published:2021


Abstract

Toxocara is one of the most prevalent nematodes in Iran, which infect humans as an intermediate host. Infection complications result from the larva migration. Human toxocariasis prevalence was various in Iran according to the area of study and population. This study was designed to evaluate the seropositivity of Toxocara IgG in patients with blood disorders and cancer patients in southwest Iran. Moreover, the study of the associated risk factors for this infection. A total of 1122 serum samples, from February 8, 2019 to August 21, 2019, including 600 healthy individuals and 522 individuals with cancer and blood disorders patients were collected. Serum samples were collected for detection of Toxocara IgG by using ELISA (Enzyme-Linked Immunosorbent Assay) kit. Sociodemographic data of all participants were collected and examined to determine their association with the infection. Out of 101 individuals with white blood cell disorders (5.94%), red blood cell disorders (7.48%) and cancer patients (11.06%) were seropositive for Toxocara IgG antibodies. The infection rate among all study population revealed that (10.76%) were positive for Toxocara IgG. This study showed the fundamental role of contact with pets and infection in groups with blood cell disorders (P-value ≤ 0.05%); while in cancer patients the association wasn’t significant. Other factors such as age, location of residence, and sex showed that the association with this infection wasn't significant. © 2021, Indian Society for Parasitology.
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