Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial

Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial Publisher Pubmed

Haraji A¹ ; Rakhshan V^{2, 3}

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1. Department of Oral and Maxillofacial Surgery, Dental Branch, Islamic Azad University, Tehran, Iran
2. Iranian Tissue Bank and Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Dental Anatomy and Morphology, Dental Branch, Islamic Azad University, Tehran, Iran

Source: Journal of Oral Rehabilitation Published:2015

Abstract

Reports on post-surgical pain are a few, controversial and flawed (by statistics and analgesic consumption). Besides, it is not known if chlorhexidine can reduce post-extraction pain adjusting for its effect on prevention of infection and dry socket (DS). We assessed these. A total of 90 impacted mandibular third molars of 45 patients were extracted. Intra-alveolar 0·2% chlorhexidine gel was applied in a split-mouth randomised design to one-half of the sockets. None of the included patients took antibiotics or analgesics afterwards. In the first and third post-operative days, DS formation and pain levels were recorded. Predictive roles of the risk factors were analysed using fixed-effects (classic) and multilevel (mixed-model) multiple linear regressions (α = 0·05, β≤0·1). In the first day, pain levels were 5·56 ± 1·53 and 4·78 ± 1·43 (out of 10), respectively. These reduced to 3·22 ± 1·41 and 2·16 ± 1·40. Pain was more intense on the control sides [both P values = 0·000 (paired t-test)]. Chlorhexidine had a significant pain-alleviating effect (P = 0·0001), excluding its effect on DS and infection. More difficult surgeries (P = 0·0201) and dry sockets were more painful (P = 0·0000). Age had a marginally significant negative role (P = 0·0994). Gender and smoking had no significant impact [P ≥ 0·7 (regression)]. The pattern of pain reduction differed between dry sockets and healthy sockets [P = 0·0102 (anova)]. Chlorhexidine can reduce pain, regardless of its infection-/DS-preventive effects. Simpler surgeries and sockets not affected by alveolar osteitis are less painful. Smoking and gender less likely affect pain. The role of age was not conclusive and needs future studies. © 2014 John Wiley & Sons Ltd.

2. Low‐Level Laser Therapy Using Laser Diode 940 Nm in the Mandibular Impacted Third Molar Surgery: Double-Blind Randomized Clinical Trial, BMC Oral Health (2021)

Experts (# of related papers)

Mahdieh-Sadat Moosavi (1)

Style	Citing Format
MLA	Haraji A, Rakhshan V. "Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial." Journal of Oral Rehabilitation, vol. 42, no. 3, 2015, pp. 209-219.
APA	Haraji A, Rakhshan V (2015). Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial. Journal of Oral Rehabilitation, 42(3), 209-219.
Chicago	Haraji A, Rakhshan V. "Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial." Journal of Oral Rehabilitation 42, no. 3 (2015): 209-219.
Harvard	Haraji A, Rakhshan V (2015) 'Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial', Journal of Oral Rehabilitation, 42(3), pp. 209-219.
Vancouver	Haraji A, Rakhshan V. Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial. Journal of Oral Rehabilitation. 2015;42(3):209-219.
BibTex	@article{ author = {Haraji A and Rakhshan V}, title = {Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial}, journal = {Journal of Oral Rehabilitation}, volume = {42}, number = {3}, pages = {209-219}, year = {2015} }
RIS	TY - JOUR AU - Haraji A AU - Rakhshan V TI - Chlorhexidine Gel and Less Difficult Surgeries Might Reduce Post-Operative Pain, Controlling for Dry Socket, Infection and Analgesic Consumption: A Split-Mouth Controlled Randomised Clinical Trial JO - Journal of Oral Rehabilitation VL - 42 IS - 3 SP - 209 EP - 219 PY - 2015 ER -

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