Shigellosis and Changes of Antimicrobial Susceptibility During Six Years

Shigellosis and Changes of Antimicrobial Susceptibility During Six Years Publisher

Ghavam P¹ ; Monajemzadeh M^{1, 2} ; Ashtiani MTH^{1, 2} ; Mamishi S^{1, 3} ; Farahani NN¹ ; Tanzifi P^{1, 2}

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1. Childrenâ€™s Medical Center, Pediatrics Center of Excellence, Tehran, Iran
2. Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pediatrics Published:2017

Abstract

Background: Shigellosis is a diarrheal disease caused by Shigella spp. The majority of cases and deaths occur among children less than 5 years old. In severe cases, antibiotic therapy is recommended to lessen the risk of serious complications and death. Prevalence of different Shigella species and their antibiotic resistance patterns are changing over the time. Objectives: The current study aimed at assessing the changes in the prevalence of Shigella species and their antibiotic susceptibility among 0- to 14-year-old children referred to Children’s Medical Center, Tehran, Iran, from 2009 to 2014. Methods: The results of stool cultures were retrospectively analyzed to determine the prevalence of different Shigella species, their antibiotic susceptibility patterns and their changes in the largest university affiliated pediatrics center in Tehran. Results: Among 40 700 stool cultures, 507 cases were positive for Shigella spp. Most cases occurred among children under 5 years old. Shigellosis was more prevalent among males. The most common species were Shigella sonnei and Shigella flexneri. In general, they were most sensitive to cefotaxime and most resistant to cotrimoxazole. Resistance to cefotaxime and nalidixic acid increased annually. Resistance to ampicillin had a descending trend. Resistance to cotrimoxazole remained almost constant. Conclusions: The most common species of Shigella changed from Shigella flexneri to Shigella sonnei over the years. In comparison with the previous studies, resistance to nalidixic acid increased and resistance to ampicillin decreased. The prevalence and antibiotic resistance patterns of Shigella species, at different times and regions are changing. To make appropriate decisions on treatment, it is necessary to monitor the changes. © 2017, Iranian Journal of Pediatrics.

Style	Citing Format
MLA	Ghavam P, et al.. "Shigellosis and Changes of Antimicrobial Susceptibility During Six Years." Iranian Journal of Pediatrics, vol. 27, no. 3, 2017, pp. -.
APA	Ghavam P, Monajemzadeh M, Ashtiani MTH, Mamishi S, Farahani NN, Tanzifi P (2017). Shigellosis and Changes of Antimicrobial Susceptibility During Six Years. Iranian Journal of Pediatrics, 27(3), -.
Chicago	Ghavam P, Monajemzadeh M, Ashtiani MTH, Mamishi S, Farahani NN, Tanzifi P. "Shigellosis and Changes of Antimicrobial Susceptibility During Six Years." Iranian Journal of Pediatrics 27, no. 3 (2017): -.
Harvard	Ghavam P et al. (2017) 'Shigellosis and Changes of Antimicrobial Susceptibility During Six Years', Iranian Journal of Pediatrics, 27(3), pp. -.
Vancouver	Ghavam P, Monajemzadeh M, Ashtiani MTH, Mamishi S, Farahani NN, Tanzifi P. Shigellosis and Changes of Antimicrobial Susceptibility During Six Years. Iranian Journal of Pediatrics. 2017;27(3):-.
BibTex	@article{ author = {Ghavam P and Monajemzadeh M and Ashtiani MTH and Mamishi S and Farahani NN and Tanzifi P}, title = {Shigellosis and Changes of Antimicrobial Susceptibility During Six Years}, journal = {Iranian Journal of Pediatrics}, volume = {27}, number = {3}, pages = {-}, year = {2017} }
RIS	TY - JOUR AU - Ghavam P AU - Monajemzadeh M AU - Ashtiani MTH AU - Mamishi S AU - Farahani NN AU - Tanzifi P TI - Shigellosis and Changes of Antimicrobial Susceptibility During Six Years JO - Iranian Journal of Pediatrics VL - 27 IS - 3 SP - EP - PY - 2017 ER -

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