Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study

Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study Publisher Pubmed

Farvid MS^{1, 2} ; Malekshah AF^{2, 3} ; Pourshams A^{2, 4} ; Poustchi H^{3, 4} ; Sepanlou SG^{2, 3} ; Sharafkhah M^{2, 4} ; Khoshnia M⁵ ; Farvid M⁶ ; Abnet CC⁷ ; Kamangar F⁸ ; Dawsey SM⁷ ; Brennan P⁹ ; Pharoah PD¹⁰ ; Boffetta P¹¹ Show All Authors

Farvid MS^{1, 2}
Malekshah AF^{2, 3}
Pourshams A^{2, 4}
Poustchi H^{3, 4}
Sepanlou SG^{2, 3}
Sharafkhah M^{2, 4}
Khoshnia M⁵
Farvid M⁶
Abnet CC⁷
Kamangar F⁸
Dawsey SM⁷
Brennan P⁹
Pharoah PD¹⁰
Boffetta P¹¹
Willett WC^{11, 12, 13}
Malekzadeh R^{2, 3, 4}

Show Affiliations

1. Department of Nutrition, Harvard T.H. Chan School of Public Health, 655 Huntington Avenue, SPH-2, Boston, 02115, MA, United States
2. Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, North Kargar Street, Tehran, Iran
3. Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4. Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
6. Vaxjo, Sweden
7. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States
8. Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, MD, United States
9. Section of Genetics, International Agency for Research on Cancer, Lyon, France
10. Departments of Oncology and Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
11. Tisch Cancer Institute, Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States
12. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
13. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

Source: American Journal of Epidemiology Published:2017

Abstract

We investigated the association between dairy product consumption and all-cause, cardiovascular disease (CVD), and cancer mortality in the Golestan Cohort Study, a prospective cohort study launched in January 2004 in Golestan Province, northeastern Iran. A total of 42,403 men and women participated in the study and completed a diet questionnaire at enrollment. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. We documented 3,291 deaths (1,467 from CVD and 859 from cancer) during 11 years of follow-up (2004-2015). The highest quintile of total dairy product consumption (versus the lowest) was associated with 19% lower all-cause mortality risk (hazard ratio (HR) = 0.81, 95% confidence interval (CI): 0.72, 0.91; Ptrend = 0.006) and 28% lower CVD mortality risk (HR = 0.72, 95% CI: 0.60, 0.86; Ptrend = 0.005). High consumption of low-fat dairy food was associated with lower risk of all-cause (HR = 0.83, 95% CI: 0.73, 0.94; Ptrend = 0.002) and CVD (HR = 0.74, 95% CI: 0.61, 0.89; Ptrend = 0.001) mortality. We noted 11% lower all-cause mortality and 16% lower CVD mortality risk with high yogurt intake. Cheese intake was associated with 16% lower all-cause mortality and 26% lower CVD mortality risk. Higher intake of high-fat dairy food and milk was not associated with all-cause or CVD mortality. Neither intake of individual dairy products nor intake of total dairy products was significantly associated with overall cancer mortality. High consumption of dairy products, especially yogurt and cheese, may reduce the risk of overall and CVD mortality. © 2017 The Author.

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Style	Citing Format
MLA	Farvid MS, et al.. "Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study." American Journal of Epidemiology, vol. 185, no. 8, 2017, pp. 697-711.
APA	Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, Khoshnia M, Farvid M, Abnet CC, Kamangar F, Dawsey SM, Brennan P, Pharoah PD, Boffetta P, Willett WC, Malekzadeh R (2017). Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study. American Journal of Epidemiology, 185(8), 697-711.
Chicago	Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, Khoshnia M, et al.. "Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study." American Journal of Epidemiology 185, no. 8 (2017): 697-711.
Harvard	Farvid MS et al. (2017) 'Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study', American Journal of Epidemiology, 185(8), pp. 697-711.
Vancouver	Farvid MS, Malekshah AF, Pourshams A, Poustchi H, Sepanlou SG, Sharafkhah M, et al.. Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study. American Journal of Epidemiology. 2017;185(8):697-711.
BibTex	@article{ author = {Farvid MS and Malekshah AF and Pourshams A and Poustchi H and Sepanlou SG and Sharafkhah M and Khoshnia M and Farvid M and Abnet CC and Kamangar F and Dawsey SM and Brennan P and Pharoah PD and Boffetta P and Willett WC and Malekzadeh R}, title = {Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study}, journal = {American Journal of Epidemiology}, volume = {185}, number = {8}, pages = {697-711}, year = {2017} }
RIS	TY - JOUR AU - Farvid MS AU - Malekshah AF AU - Pourshams A AU - Poustchi H AU - Sepanlou SG AU - Sharafkhah M AU - Khoshnia M AU - Farvid M AU - Abnet CC AU - Kamangar F AU - Dawsey SM AU - Brennan P AU - Pharoah PD AU - Boffetta P AU - Willett WC AU - Malekzadeh R TI - Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality: The Golestan Cohort Study JO - American Journal of Epidemiology VL - 185 IS - 8 SP - 697 EP - 711 PY - 2017 ER -

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