Nlrp3 Inflammasome: Significance and Potential Therapeutic Targets to Advance Solid Organ Transplantation Publisher Pubmed



Davoodi Karsalari P¹ ; Asna Ashari K^{1, 2, 3} ; Rezaei N^{1, 4}
Source: Expert Opinion on Therapeutic Targets Published:2025

Abstract

Introduction: NOD-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome, integral to innate immunity, has become a pivotal figure in the inflammatory cascade. Areas covered: This article provides an overview of the NLRP3 inflammasome, reviewing its complicated structure, as well as the diverse signals that trigger its assembly. Furthermore, we explored the intricate relationship between the NLRP3 inflammasome and acute and chronic rejection in solid organ transplantation. Solid organ transplantation stands as a crucial medical intervention, yet its efficacy is challenged by immune-mediated complications, including acute rejection, ischemia-reperfusion injury, and chronic allograft rejection. We also investigated the encouraging potential of immunosuppressive therapies targeting NLRP3 signaling to alleviate inflammatory responses linked to transplantation. Expert opinion: In recent years, the NLRP3 inflammasome has garnered considerable attention owing to its critical functions spanning diverse fields. This study highlights the critical function of the NLRP3 inflammasome and presents insights, offering fresh perspectives on how its modulation might help to improve the outcomes among patients who undergo solid organ transplantations. © 2025 Informa UK Limited, trading as Taylor & Francis Group.