Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B

Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B Publisher

Ghassemi F¹ ; Ghadimi H¹ ; Nikdel M¹

Show Affiliations

1. Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Tehran, 13366, Iran

Source: Journal of Ophthalmic and Vision Research Published:2015

Abstract

Purpose: To report a case of primary acquired melanosis (PAM) successfully treated with combined topical mitomycin C and interferon-α2b. Case Report: A 75-year-old man presented with an extensive unilateral pigmented lesion involving 360° of the bulbar conjunctiva, extending to the fornices and palpebral conjunctiva. Map biopsy confirmed PAM with local atypia. Treatment was initiated with mitomycin C 0.04% eye drops for two courses. Although the lesion markedly responded to the treatment, residual lesions justified further therapy. To avoid ocular surface toxicity induced by excessive mitomycin C exposure, interferon-α2b eye drops were started and continued for 6 months. The pigmented lesion almost completely disappeared and no significant complication or recurrence was observed for 24 months. Conclusion: Combination therapy using mitomycin C and interferon-α2b for PAM with atypia may be recommended as an effective treatment modality, avoiding the ocular surface toxicity due to excessive mitomycin C exposure.

Style	Citing Format
MLA	Ghassemi F, Ghadimi H, Nikdel M. "Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B." Journal of Ophthalmic and Vision Research, vol. 10, no. 1, 2015, pp. 84-86.
APA	Ghassemi F, Ghadimi H, Nikdel M (2015). Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B. Journal of Ophthalmic and Vision Research, 10(1), 84-86.
Chicago	Ghassemi F, Ghadimi H, Nikdel M. "Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B." Journal of Ophthalmic and Vision Research 10, no. 1 (2015): 84-86.
Harvard	Ghassemi F, Ghadimi H, Nikdel M (2015) 'Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B', Journal of Ophthalmic and Vision Research, 10(1), pp. 84-86.
Vancouver	Ghassemi F, Ghadimi H, Nikdel M. Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B. Journal of Ophthalmic and Vision Research. 2015;10(1):84-86.
BibTex	@article{ author = {Ghassemi F and Ghadimi H and Nikdel M}, title = {Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B}, journal = {Journal of Ophthalmic and Vision Research}, volume = {10}, number = {1}, pages = {84-86}, year = {2015} }
RIS	TY - JOUR AU - Ghassemi F AU - Ghadimi H AU - Nikdel M TI - Resolution of Primary Acquired Melanosis With Atypia After Treatment With Topical Mitomycin C and Interferon Alfa-2B JO - Journal of Ophthalmic and Vision Research VL - 10 IS - 1 SP - 84 EP - 86 PY - 2015 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract