Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter

Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter Publisher

Khayamian MA^{1, 2} ; Abadijoo H^{1, 3} ; Shalileh S^{1, 3} ; Ghaderinia M^{1, 3} ; Simaee H^{1, 3} ; Abbasvandi F^{1, 3, 4} ; Esmailinejad MR⁵ ; Sanati H⁴ ; Ghafari H^{1, 3} ; Parizi MS^{1, 3} ; Vanaei S^{1, 3} ; Akbari N^{1, 3} ; Karimi A^{1, 3} ; Yazdanparast SM^{1, 3} Show All Authors

Khayamian MA^{1, 2}
Abadijoo H^{1, 3}
Shalileh S^{1, 3}
Ghaderinia M^{1, 3}
Simaee H^{1, 3}
Abbasvandi F^{1, 3, 4}
Esmailinejad MR⁵
Sanati H⁴
Ghafari H^{1, 3}
Parizi MS^{1, 3}
Vanaei S^{1, 3}
Akbari N^{1, 3}
Karimi A^{1, 3}
Yazdanparast SM^{1, 3}
Pouria FR^{1, 3}
Ghabraie B^{1, 3}
Faramarzpour M^{1, 3}
Shakibi R⁶
Kousha E^{1, 3}
Zandi A^{1, 3}
Hoseinpour P^{1, 3, 7}
Vajhi A⁵
Sarramiforooshani R⁴
Abdolahad M^{1, 3, 8}

Source: Nano Energy Published:2023

Abstract

Even though cancer therapeutic methods are improving rapidly, cancer recurrence has always remained a big challenge. Even a small lesion of missed neoplastic cells during the surgery can result in tumor recurrence and the consequent silent metastasis, making this issue more critical and complicated for prognosis. Hence, developing new methods with capability of clearing margins without side effects to the healthy surrounding tissues has always been a significant concern. This study introduced a method to prevent cancer recurrence by exposing cavity side margins to irreversible electroporation (IRE) through a balloon catheter. For this purpose, the induced tumor in BALB/c mice (as in-vivo animal model) is mostly resected, and just a traceable part is left as a model of the involved margin. A balloon-catheter is then filled with the conductive saline and inserted into the postoperative cavity. The IRE is applied through a low-cost high-voltage triboelectric nanogenerator (TENG) that is connected to the balloon catheter. Delivering a homogenous IRE without any muscle contraction by the elastic spherical balloon ensures that all the margin surfaces are exposed to the electric field. Monitoring the size of the remained tumor by the sonography imaging reveals that just 15 days of TENG-based balloon catheter irreversible electroporation (TBC-IRE) reduces the size of remained tumor by 94%, while 303% growth is observed in the remained tumor of control group of mice. Further histological analysis of this treatment disclosed no remarkable side effects on the adjacent tissue or organ. Everything considered, margin therapy by TBC-IRE can be a promising method for preventing cancer recurrence and potentially improving cancer-bearing patients' survival. © 2023 Elsevier Ltd

2. Nanoporous Platinum Needle for Cancer Tumor Destruction by Echt and Impedance-Based Intra-Therapeutic Monitoring, Nanoscale (2020)

3. Electrochemical Therapy (Echt) of Cancer Tumor With an External Anode, a Way to Achieve Pathological Complete Response, Medical Oncology (2023)

Style	Citing Format
MLA	Khayamian MA, et al.. "Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter." Nano Energy, vol. 112, no. , 2023, pp. -.
APA	Khayamian MA, Abadijoo H, Shalileh S, Ghaderinia M, Simaee H, Abbasvandi F, Esmailinejad MR, Sanati H, Ghafari H, Parizi MS, Vanaei S, Akbari N, Karimi A, Yazdanparast SM, Pouria FR, Ghabraie B, Faramarzpour M, Shakibi R, Kousha E, ... Abdolahad M (2023). Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter. Nano Energy, 112(), -.
Chicago	Khayamian MA, Abadijoo H, Shalileh S, Ghaderinia M, Simaee H, Abbasvandi F, Esmailinejad MR, et al.. "Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter." Nano Energy 112, no. (2023): -.
Harvard	Khayamian MA et al. (2023) 'Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter', Nano Energy, 112(), pp. -.
Vancouver	Khayamian MA, Abadijoo H, Shalileh S, Ghaderinia M, Simaee H, Abbasvandi F, et al.. Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter. Nano Energy. 2023;112():-.
BibTex	@article{ author = {Khayamian MA and Abadijoo H and Shalileh S and Ghaderinia M and Simaee H and Abbasvandi F and Esmailinejad MR and Sanati H and Ghafari H and Parizi MS and Vanaei S and Akbari N and Karimi A and Yazdanparast SM and Pouria FR and Ghabraie B and Faramarzpour M and Shakibi R and Kousha E and Zandi A and Hoseinpour P and Vajhi A and Sarramiforooshani R and Abdolahad M}, title = {Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter}, journal = {Nano Energy}, volume = {112}, number = {}, pages = {-}, year = {2023} }
RIS	TY - JOUR AU - Khayamian MA AU - Abadijoo H AU - Shalileh S AU - Ghaderinia M AU - Simaee H AU - Abbasvandi F AU - Esmailinejad MR AU - Sanati H AU - Ghafari H AU - Parizi MS AU - Vanaei S AU - Akbari N AU - Karimi A AU - Yazdanparast SM AU - Pouria FR AU - Ghabraie B AU - Faramarzpour M AU - Shakibi R AU - Kousha E AU - Zandi A AU - Hoseinpour P AU - Vajhi A AU - Sarramiforooshani R AU - Abdolahad M TI - Irreversible Electroporation for Post-Operative Margin Therapy to Prevent Cancer Recurrence Based on Triboelectric Nanogenerator Driven Balloon Catheter JO - Nano Energy VL - 112 IS - SP - EP - PY - 2023 ER -

Science Communicator Platform

Authors

Abstract