Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia

Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia Publisher Pubmed

Amini P¹ ; Nodooshan SJ² ; Ashrafizadeh M^{3, 4} ; Aliasgharzadeh A⁵ ; Vakili Z⁶ ; Tavakoli S⁷ ; Aryafar T⁸ ; Musa AE⁸ ; Najafi M⁹ ; Taeb S^{10, 11} ; Farhood B⁴

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1. Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
3. Sabanci University Nanotechnology Research and Application Center (SUNUM), Istanbul, Tuzla, 34956, Turkey
4. Faculty of Engineering andNatural Sciences, Sabanci UniVersitY, Orta Mahalle, UniVersite Caddesi No. 27, Orhanli, Istanbul, Tuzla, 34956, Turkey
5. Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran
6. Department of Pathology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
7. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
8. De-partment of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
9. Medical Technology Research Center, Institute of Health Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
10. Department of Radiology, School of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran
11. Medical Biotechnology Research Center, School of Paramedical Sciences, Guilan University of Medical Sciences, Rasht, Iran

Source: Current Radiopharmaceuticals Published:2022

Abstract

Background: Breast cancer is one of the most common types of malignancies in the world. Cancer resistance is an unavoidable consequence of therapy with radiation or other modalities. On-going research aims to improve cancer response to therapy. Aim: The aim of this study was to evaluate the possible sensitization effect of imperatorin (IMP) in combination with external radiotherapy (ERT) or HT. Methods: After treatment of MCF-7 breast cancer cells with IMP, cells were exposed to 4 Gy X-rays or HT (42 °C for 1 hour). The viability of MCF-7 cells was measured using an MTT assay. Further-more, the expression of pro-apoptotic genes, including Bax, Bcl-2, caspase-3, caspase-8, and caspase-9, was investigated using real-time PCR. The sensitizing effect of IMP in combination with ERT or HT was calculated and compared to ERT or HT alone. Results: Results showed an increase in the expression of pro-apoptotic genes and downregulation of anti-apoptotic Bcl-2 following ERT and HT. Furthermore, cell viability was reduced following these treatments. IMP was able to augment these effects of ERT and HT. Conclusion: IMP could increase the efficiency of HT and ERT. This effect of IMP may suggest it as an adjuvant for increasing the therapeutic efficiency of ERT. © 2022 Bentham Science Publishers.

2. Resveratrol Induces Apoptosis and Attenuates Proliferation of Mcf-7 Cells in Combination With Radiation and Hyperthermia, Current Molecular Medicine (2021)

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Seyed Mohammad Eftekhari (1)

Style	Citing Format
MLA	Amini P, et al.. "Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia." Current Radiopharmaceuticals, vol. 15, no. 3, 2022, pp. 236-241.
APA	Amini P, Nodooshan SJ, Ashrafizadeh M, Aliasgharzadeh A, Vakili Z, Tavakoli S, Aryafar T, Musa AE, Najafi M, Taeb S, Farhood B (2022). Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia. Current Radiopharmaceuticals, 15(3), 236-241.
Chicago	Amini P, Nodooshan SJ, Ashrafizadeh M, Aliasgharzadeh A, Vakili Z, Tavakoli S, Aryafar T, et al.. "Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia." Current Radiopharmaceuticals 15, no. 3 (2022): 236-241.
Harvard	Amini P et al. (2022) 'Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia', Current Radiopharmaceuticals, 15(3), pp. 236-241.
Vancouver	Amini P, Nodooshan SJ, Ashrafizadeh M, Aliasgharzadeh A, Vakili Z, Tavakoli S, et al.. Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia. Current Radiopharmaceuticals. 2022;15(3):236-241.
BibTex	@article{ author = {Amini P and Nodooshan SJ and Ashrafizadeh M and Aliasgharzadeh A and Vakili Z and Tavakoli S and Aryafar T and Musa AE and Najafi M and Taeb S and Farhood B}, title = {Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia}, journal = {Current Radiopharmaceuticals}, volume = {15}, number = {3}, pages = {236-241}, year = {2022} }
RIS	TY - JOUR AU - Amini P AU - Nodooshan SJ AU - Ashrafizadeh M AU - Aliasgharzadeh A AU - Vakili Z AU - Tavakoli S AU - Aryafar T AU - Musa AE AU - Najafi M AU - Taeb S AU - Farhood B TI - Imperatorin Attenuates the Proliferation of Mcf-7 Cells in Combination With Radiotherapy or Hyperthermia JO - Current Radiopharmaceuticals VL - 15 IS - 3 SP - 236 EP - 241 PY - 2022 ER -

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