Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion

Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion Publisher Pubmed

Sabbaghian M¹ ; Mohseni Meybodi A² ; Rafaee A¹ ; Saba S¹ ; Zamanian M² ; Sadighi Gilani MA^{1, 3}

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1. Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
2. Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran
3. Department of Urology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Andrologia Published:2018

Abstract

To evaluate the success rate in sperm retrieval (SR) through microdissection testicular sperm extraction (micro-TESE) in infertile azoospermia factor c (AZFc)-deleted men and determining their reproductive outcomes following ICSI, medical records of couples with AZFc-deleted male partners were reviewed on patient's age, serum hormone levels, karyotype, testicular pathology and pregnancy outcomes. A comparison on age and serum hormone level was conducted between groups with positive and negative sperm retrieval in both azoospermic and oligozoospermic AZFc-deleted men. Of 225 who had AZFc deletion, 195 cases followed clinical treatments. From 195 cases, 116 were azoospermic, 79 were oligozoospermic. Pathology profile was available in 103 of 195 subjects which the predominant trait was SCOS and was seen in 66.9% of cases (69 of 103). Success rate of sperm retrieval in azoospermic patients who underwent micro-TESE was 36.3% (28/77). Forty-three oligozoospermic and 17 azoospermic patients started ART cycle. Pregnancy rate in oligozoospermic group was 35.4% (17 cases), whilst there was no clinical pregnancy in azoospermic group. In conclusion, the pregnancy and delivery in oligozoospermic patients with AZFc deletion are comparable with other studies, but despite of sperm retrieval in azoospermic patients with AZFc deletion, the chance of pregnancy or delivery in these patients was very low. © 2018 Blackwell Verlag GmbH

Style	Citing Format
MLA	Sabbaghian M, et al.. "Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion." Andrologia, vol. 50, no. 7, 2018, pp. -.
APA	Sabbaghian M, Mohseni Meybodi A, Rafaee A, Saba S, Zamanian M, Sadighi Gilani MA (2018). Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion. Andrologia, 50(7), -.
Chicago	Sabbaghian M, Mohseni Meybodi A, Rafaee A, Saba S, Zamanian M, Sadighi Gilani MA. "Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion." Andrologia 50, no. 7 (2018): -.
Harvard	Sabbaghian M et al. (2018) 'Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion', Andrologia, 50(7), pp. -.
Vancouver	Sabbaghian M, Mohseni Meybodi A, Rafaee A, Saba S, Zamanian M, Sadighi Gilani MA. Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion. Andrologia. 2018;50(7):-.
BibTex	@article{ author = {Sabbaghian M and Mohseni Meybodi A and Rafaee A and Saba S and Zamanian M and Sadighi Gilani MA}, title = {Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion}, journal = {Andrologia}, volume = {50}, number = {7}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Sabbaghian M AU - Mohseni Meybodi A AU - Rafaee A AU - Saba S AU - Zamanian M AU - Sadighi Gilani MA TI - Sperm Retrieval Rate and Reproductive Outcome of Infertile Men With Azoospermia Factor C Deletion JO - Andrologia VL - 50 IS - 7 SP - EP - PY - 2018 ER -

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