Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy

Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy Publisher Pubmed

Nakhjavani M¹ ; Nargesi AA¹ ; Heidari B¹ ; Ghazizadeh Z¹ ; Larry M¹ ; Esteghamati A¹

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1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, PO Box 13145-784, Tehran, Iran

Source: Diabetes and Vascular Disease Research Published:2015

Abstract

We aimed to study whether pulse pressure (PP) predicts the response of diabetic nephropathy to glucose-lowering treatment. Patients with uncontrolled type 2 diabetes were followed for decrease in albuminuria after insulin/oral-hypoglycemic treatment. A total of 143 patients were followed for a median time of 10.5 months in a cohort study. Fasting blood sugar and HbA1C significantly decreased, while systolic, diastolic and pulse pressures remained constant during intervention. Median albuminuria decreased from 18.4 mg/day [10-40] to 16.4 mg/day [9-28] at the end of study (p-value < 0.005). The number of patients with normo/micro/macro-albuminuria changed from 98/36/9 to 108/31/4 (p-value < 0.001). No significant difference in baseline PP (47.5 ±1.61 vs. 45.9 ±1.81 mmHg; p-value = 0.51) or final PP (47.0 ±2.41 vs. 49.4 ±2.38 mmHg; p-value = 0.47) existed between those with decreased and increased albuminuria. PP was not a significant predictor of albuminuria changes in receiver operating characteristic curve (p-value = 0.77) and regression (p-value = 0.98) analyses. Benefits of glycemic control in diabetic nephropathy are independent of PP. © The Author(s) 2014.

Style	Citing Format
MLA	Nakhjavani M, et al.. "Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy." Diabetes and Vascular Disease Research, vol. 12, no. 2, 2015, pp. 150-151.
APA	Nakhjavani M, Nargesi AA, Heidari B, Ghazizadeh Z, Larry M, Esteghamati A (2015). Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy. Diabetes and Vascular Disease Research, 12(2), 150-151.
Chicago	Nakhjavani M, Nargesi AA, Heidari B, Ghazizadeh Z, Larry M, Esteghamati A. "Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy." Diabetes and Vascular Disease Research 12, no. 2 (2015): 150-151.
Harvard	Nakhjavani M et al. (2015) 'Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy', Diabetes and Vascular Disease Research, 12(2), pp. 150-151.
Vancouver	Nakhjavani M, Nargesi AA, Heidari B, Ghazizadeh Z, Larry M, Esteghamati A. Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy. Diabetes and Vascular Disease Research. 2015;12(2):150-151.
BibTex	@article{ author = {Nakhjavani M and Nargesi AA and Heidari B and Ghazizadeh Z and Larry M and Esteghamati A}, title = {Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy}, journal = {Diabetes and Vascular Disease Research}, volume = {12}, number = {2}, pages = {150-151}, year = {2015} }
RIS	TY - JOUR AU - Nakhjavani M AU - Nargesi AA AU - Heidari B AU - Ghazizadeh Z AU - Larry M AU - Esteghamati A TI - Pulse Pressure Does Not Predict the Response of Diabetic Nephropathy to Glucose-Lowering Therapy JO - Diabetes and Vascular Disease Research VL - 12 IS - 2 SP - 150 EP - 151 PY - 2015 ER -

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