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The Value of Anti-Drug Antibody Detection in Discriminating Patients From Healthy Controls and Predicting the Gross Motor Functional State in Patients With Pompe Disease Publisher Pubmed



Azizahari S ; Aminian M ; Rahimian A ; Nafissi S ; Heidari M ; Rabbani A ; Zarnani AH ; Mohebbi A ; Badv RS ; Saladjegheh N ; Mortezagholi S ; Masoumi S ; Hadipour Z ; Boostani R Show All Authors
Authors
  1. Azizahari S
  2. Aminian M
  3. Rahimian A
  4. Nafissi S
  5. Heidari M
  6. Rabbani A
  7. Zarnani AH
  8. Mohebbi A
  9. Badv RS
  10. Saladjegheh N
  11. Mortezagholi S
  12. Masoumi S
  13. Hadipour Z
  14. Boostani R
  15. Toosi MB
  16. Zanjani KS
  17. Khajeh A
  18. Tonkaboni SH
  19. Sadeghi M
  20. Fatehi F
  21. Vafaei E
  22. Ashrafi MR

Source: Iranian Journal of Allergy, Asthma and Immunology Published:2026


Abstract

Anti-recombinant human acid α-glucosidase (anti-rhGAA) antibody formation is a major challenge in patients with Pompe disease receiving enzyme replacement therapy (ERT). The clinical significance of these antibodies and their detection methods remain uncertain. This study aimed to evaluate the diagnostic and functional relevance of anti-rhGAA antibodies in late- onset Pompe Copyright © 2026 Aziz-Ahari et al.