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Hope on the Horizon? Aptamers in Diagnosis of Invasive Fungal Infections Publisher Pubmed



Khodavaisy S1, 2 ; Xu J1
Authors
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Authors Affiliations
  1. 1. Department of Biology, McMaster University, Hamilton, L8S 4K1, ON, Canada
  2. 2. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417613151, Iran

Source: Genes Published:2024


Abstract

Despite remarkable advances in the diagnosis of invasive fungal infections (IFIs), rapid, specific, sensitive, and cost-effective detection methods remain elusive. Due to their stability, ease of production, and specificity to signature molecules of fungal pathogens, short single-stranded sequences of DNA, RNA, and XNA, collectively called aptamers, have emerged as promising diagnostic markers. In this perspective, we summarize recent progress in aptamer-based diagnostic tools for IFIs and discuss how these tools could potentially meet the needs and provide economical and simple solutions for point-of-care for better management of IFIs. © 2024 by the authors.