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Celiac Disease: A Review From Genetic to Treatment Publisher Pubmed



Jafari E1 ; Soleymani N2 ; Hamidi M3 ; Rahi A4 ; Rezaei A5 ; Azizian R1, 6
Authors
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Authors Affiliations
  1. 1. Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Food Hygiene, Islamic Azad University (Science and Research Branch), Tehran, Iran
  3. 3. Ecole Polytechnique de Bruxelles-BioMatter Unit, Universite Libre de Bruxelles (ULB), Brussels, Belgium
  4. 4. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Biomedical Innovation and Start-Up Association (Biomino), Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Biomedical Journal Published:2024


Abstract

Celiac disease is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood. Influence of genetic factors on CD development is evident in carriers of the DQ2 and/or DQ8 allele. HLA genotypes are associated with gut colonization by bacteria, particularly in individuals suffering from CD. In addition, beneficial gut microbes are crucial for the production of DPP-4, which plays a key role in immune function, as well as metabolic and intestinal health. Therefore, probiotics have been recommended as a complementary food supplement in CD. © 2024, Pasteur Institute of Iran. All rights reserved.
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