The Usefulness of Endometrial Receptivity Biomarkers As Predictors of Ivf Outcome Publisher



Aljarah ZA ; Hameed RM ; Al Safi WG
Source: Journal of Associated Medical Sciences Published:2026

Abstract

Background: Despite the progress in assisted reproductive technology, predicting in vitro fertilization (IVF) success remains challenging. Objectives: This study aimed to investigate the relationship between endometrial receptivity biomarkers and Ovarian Sensitivity Index (OSI) as predictors of IVF outcomes. Materials and methods: A total of 72 women undergoing IVF treatment, between December 2023 and July 2024, participated in this study. Serum levels of MUC1, GDF-9, and HLA were measured, OSI was calculated, and pregnancy outcomes (β-hCG) were recorded. Participants were divided into two groups based on OSI (≤4 and >4), and biomarker levels were compared. Correlation analysis, ROC curves, and logistic regression models were used to assess predictive capabilities. Results: OSI showed strong predictive value (AUC=0.751, 95% CI: 0.613-0.859, p<0.05) with a threshold of >8 (sensitivity=52.63%, specificity=94.12%). Endometrial biomarkers showed limited individual predictive capacity (AUCs: MUC1=0.625, GDF-9=0.507, HLA=0.589). OSI retained significant association with pregnancy outcomes across all regression models (OR=1.19-1.38, p<0.05). Combining hormonal parameters with OSI significantly improved model performance (AUC=0.867, R²=0.509). Significant correlations were observed between OSI and hormonal parameters, particularly AMH (r=0.66, p<0.05) and E2 (r=0.49, p<0.05). Conclusion: While endometrial receptivity biomarkers showed limited individual predictive value, the incorporation of OSI with hormonal parameters provides better predictive value of IVF outcomes, suggesting the importance of a comprehensive assessment in assisted reproduction. © 2026, Faculty of Associated Medical Sciences, Chiang Mai University. All rights reserved.