The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts

The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts Publisher Pubmed

Recke A^{1, 2} ; Konitzer S¹ ; Lemcke S¹ ; Freitag M¹ ; Sommer NM¹ ; Abdelhady M³ ; Amoli MM⁴ ; Benoit S⁵ ; Elchennawy F⁶ ; Eldarouti M³ ; Eming R⁷ ; Glaser R⁸ ; Gunther C⁹ ; Hadaschik E¹⁰ Show All Authors

Recke A^{1, 2}
Konitzer S¹
Lemcke S¹
Freitag M¹
Sommer NM¹
Abdelhady M³
Amoli MM⁴
Benoit S⁵
Elchennawy F⁶
Eldarouti M³
Eming R⁷
Glaser R⁸
Gunther C⁹
Hadaschik E¹⁰
Homey B¹¹
Lieb W^{12, 13}
Peitsch WK^{14, 15}
Pfohler C¹⁶
Robati RM¹⁷
Saeedi M¹⁷
Sardy M¹⁸
Sticherling M¹⁹
Uzun S²⁰
Worm M²¹
Zillikens D²
Ibrahim S¹
Vidarsson G²²
Schmidt E¹
Kreuter A^{23, 24}
Zouboulis CC²⁵
Daschlein G²⁶
Steinbrink K²⁷
Kunz M²⁸
Hunzelmann N²⁹
Goetze S³⁰

Show Affiliations

1. Lubeck Institute of Experimental Dermatology (LIED), University of Lubeck, Lubeck, Germany
2. Department of Dermatology, Allergology and Venereology, University of Lubeck, Lubeck, Germany
3. Department of Dermatology, Faculty of Medicine, Cairo University, Giza, Egypt
4. Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular - Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Dermatology, Venereology and Allergology, University Hospital Wurzburg, Wurzburg, Germany
6. Department of Clinical Pathology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt
7. Department of Dermatology and Allergology, Phillips-Universitat Marburg, Marburg, Germany
8. Department of Dermatology, Venereology and Allergology, Christian Albrecht University, Kiel, Germany
9. Department of Dermatology, University Hospital of Dresden, Dresden, Germany
10. Department of Dermatology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany
11. Department of Dermatology, Heinrich Heine University, Dusseldorf, Germany
12. Institute of Epidemiology, Christian-Albrechts-University, Kiel, Germany
13. Popgen Biobank, Christian-Albrechts-University, Kiel, Germany
14. Department of Dermatology, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany
15. Department of Dermatology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
16. Department of Dermatology, Saarland University Medical School, Homburg/Saar, Germany
17. Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
18. Department of Dermatology, Ludwig Maximilian University Munich, Munich, Germany
19. Department of Dermatology, University of Erlangen-Nuremberg, Erlangen, Germany
20. Department of Dermatology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
21. Department of Dermatology, Venerology and Allergology, Allergy Center Charite, Charite-Medical University Berlin, Berlin, Germany
22. Department of Experimental Hematology, Sanquin Research Institute, Amsterdam, Netherlands
23. Department of Dermatology, Venereology and Allergology, University of Bochum, Bochum, Germany
24. Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Klinik Oberhausen, Oberhausen, Germany
25. Department of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany
26. Department of Dermatology, University of Greifswald, Greifswald, Germany
27. Department of Dermatology, University Medical Center Mainz, University of Mainz, Mainz, Germany
28. Department of Dermatology, Venereology and Allergology, University of Leipzig, Leipzig, Germany
29. Department of Dermatology, University of Cologne, Cologne, Germany
30. Department of Dermatology, University Hospital Jena, Jena, Germany

Source: Frontiers in Immunology Published:2018

Abstract

IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with the other IgG subclasses, it has a reduced half-life which is probably connected to a decreased affinity to the neonatal Fc receptor (FcRn). However, a few allelic variants harbor an amino acid replacement of His435 to Arg that reverts the half-life of the resulting IgG3 to the same level as the other IgG subclasses. Because of its functional impact, we hypothesized that the p.Arg435His variation could be associated with susceptibility to autoantibody-mediated diseases like pemphigus vulgaris (PV) and bullous pemphigoid (BP). Using a set of samples from German, Turkish, Egyptian, and Iranian patients and controls, we were able to demonstrate a genetic association of the p.Arg435His variation with PV risk, but not with BP risk. Our results suggest a hitherto unknown role for the function of IgG3 in the pathogenesis of PV. © 2018 Recke, Konitzer, Lemcke, Freitag, Sommer, Abdelhady, Amoli, Benoit, El-Chennawy, Eldarouti, Eming, Glaser, Gunther, Hadaschik, Homey, Lieb, Peitsch, Pfohler, Robati, Saeedi, Sardy, Sticherling, Uzun, Worm, Zillikens, Ibrahim, Vidarsson, Schmidt and the German AIBD Genetic Study Group.

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Style	Citing Format
MLA	Recke A, et al.. "The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts." Frontiers in Immunology, vol. 9, no. AUG, 2018, pp. -.
APA	Recke A, Konitzer S, Lemcke S, Freitag M, Sommer NM, Abdelhady M, Amoli MM, Benoit S, Elchennawy F, Eldarouti M, Eming R, Glaser R, Gunther C, Hadaschik E, Homey B, Lieb W, Peitsch WK, Pfohler C, Robati RM, ... Goetze S (2018). The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts. Frontiers in Immunology, 9(AUG), -.
Chicago	Recke A, Konitzer S, Lemcke S, Freitag M, Sommer NM, Abdelhady M, Amoli MM, et al.. "The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts." Frontiers in Immunology 9, no. AUG (2018): -.
Harvard	Recke A et al. (2018) 'The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts', Frontiers in Immunology, 9(AUG), pp. -.
Vancouver	Recke A, Konitzer S, Lemcke S, Freitag M, Sommer NM, Abdelhady M, et al.. The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts. Frontiers in Immunology. 2018;9(AUG):-.
BibTex	@article{ author = {Recke A and Konitzer S and Lemcke S and Freitag M and Sommer NM and Abdelhady M and Amoli MM and Benoit S and Elchennawy F and Eldarouti M and Eming R and Glaser R and Gunther C and Hadaschik E and Homey B and Lieb W and Peitsch WK and Pfohler C and Robati RM and Saeedi M and Sardy M and Sticherling M and Uzun S and Worm M and Zillikens D and Ibrahim S and Vidarsson G and Schmidt E and Kreuter A and Zouboulis CC and Daschlein G and Steinbrink K and Kunz M and Hunzelmann N and Goetze S}, title = {The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts}, journal = {Frontiers in Immunology}, volume = {9}, number = {AUG}, pages = {-}, year = {2018} }
RIS	TY - JOUR AU - Recke A AU - Konitzer S AU - Lemcke S AU - Freitag M AU - Sommer NM AU - Abdelhady M AU - Amoli MM AU - Benoit S AU - Elchennawy F AU - Eldarouti M AU - Eming R AU - Glaser R AU - Gunther C AU - Hadaschik E AU - Homey B AU - Lieb W AU - Peitsch WK AU - Pfohler C AU - Robati RM AU - Saeedi M AU - Sardy M AU - Sticherling M AU - Uzun S AU - Worm M AU - Zillikens D AU - Ibrahim S AU - Vidarsson G AU - Schmidt E AU - Kreuter A AU - Zouboulis CC AU - Daschlein G AU - Steinbrink K AU - Kunz M AU - Hunzelmann N AU - Goetze S TI - The P.Arg435his Variation of Igg3 With High Affinity to Fcrn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts JO - Frontiers in Immunology VL - 9 IS - AUG SP - EP - PY - 2018 ER -

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