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Association of Serum Pcsk9 Levels With Antibiotic Resistance and Severity of Disease in Patients With Bacterial Infections Admitted to Intensive Care Units Publisher



Jamialahmadi T1, 2 ; Panahi Y3 ; Safarpour MA4 ; Ganjali S5 ; Chahabi M6 ; Reiner Z7 ; Solgi S6 ; Vahedianazimi A8 ; Kianpour P9 ; Banach M10, 11 ; Sahebkar A12, 13, 14
Authors
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Authors Affiliations
  1. 1. Halal Research Center of IRI, FDA, Tehran, Iran
  2. 2. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  3. 3. Pharmacotherapy Department, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, 143591647, Iran
  4. 4. Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran
  6. 6. Department of Biochemistry, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, 37515374, Iran
  7. 7. University Hospital Center Zagreb, Department of Internal medicine, Kispaticeva 12, Zagreb, 10000, Croatia
  8. 8. Trauma Research Center, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran
  9. 9. Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 1417614411, Iran
  10. 10. Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Lodz, 90549, Poland
  11. 11. Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Lodz, 93338, Poland
  12. 12. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  13. 13. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  14. 14. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, 9177948567, Iran

Source: Journal of Clinical Medicine Published:2019


Abstract

Background: The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients with bacterial infections in intensive care units, the aim of this study was to investigate whether any such associations exist. Methods: 100 patients (46 males, mean age 67.12 ± 1.34 years) with bacterial infections who were staying in an intensive care unit (ICU) longer than 48 h but less than 7 days and who were not receiving corticosteroids were analyzed. Their serum levels of albumin, C-reactive protein, glucose, lactate, blood urea nitrogen, prothrombin (international normalized ratio), total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, PCSK9, and procalcitonin were measured. The severity of the patients’ condition was assessed by using the Glasgow Coma Scale (GCS), the Sequential Organ Failure Assessment (SOFA), and the Acute Physiology and Chronic Health Evaluation II (APACHE II) scales. Results: Using a hierarchical regression modeling approach, no significant association was found between PCSK9 levels and either the severity of disease (APACHE II, SOFA, and GCS) indices or resistance to antibiotics. Conclusion: The results suggest that there is no association between PCSK9 levels and resistance to antibiotics or the condition of patients hospitalized in intensive care units. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
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